2kx4: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
Line 1: Line 1:


==Solution structure of Bacteriophage Lambda gpFII==
==Solution structure of Bacteriophage Lambda gpFII==
<StructureSection load='2kx4' size='340' side='right'caption='[[2kx4]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2kx4' size='340' side='right'caption='[[2kx4]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteriophage_lambda Bacteriophage lambda]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KX4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KX4 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FII ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10710 Bacteriophage lambda])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kx4 OCA], [https://pdbe.org/2kx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kx4 RCSB], [https://www.ebi.ac.uk/pdbsum/2kx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kx4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kx4 OCA], [https://pdbe.org/2kx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kx4 RCSB], [https://www.ebi.ac.uk/pdbsum/2kx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kx4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/FII_LAMBD FII_LAMBD]] Plays a role in virion assembly by joining the head and the tail at the last step of morphogenesis. Six FII proteins bind the DNA-filled capsid after W binding, in turn binding the pre-assembled tail by interacting with U protein.<ref>PMID:4413519</ref> <ref>PMID:4616093</ref> <ref>PMID:5022189</ref>
[https://www.uniprot.org/uniprot/FII_LAMBD FII_LAMBD] Plays a role in virion assembly by joining the head and the tail at the last step of morphogenesis. Six FII proteins bind the DNA-filled capsid after W binding, in turn binding the pre-assembled tail by interacting with U protein.<ref>PMID:4413519</ref> <ref>PMID:4616093</ref> <ref>PMID:5022189</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 19: Line 19:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kx4 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kx4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Evolutionary relationships may exist among very diverse groups of proteins even though they perform different functions and display little sequence similarity. The tailed bacteriophages present a uniquely amenable system for identifying such groups because of their huge diversity yet conserved genome structures. In this work, we used structural, functional, and genomic context comparisons to conclude that the head-tail connector protein and tail tube protein of bacteriophage lambda diverged from a common ancestral protein. Further comparisons of tertiary and quaternary structures indicate that the baseplate hub and tail terminator proteins of bacteriophage may also be part of this same family. We propose that all of these proteins evolved from a single ancestral tail tube protein fold, and that gene duplication followed by differentiation led to the specialized roles of these proteins seen in bacteriophages today. Although this type of evolutionary mechanism has been proposed for other systems, our work provides an evolutionary mechanism for a group of proteins with different functions that bear no sequence similarity. Our data also indicate that the addition of a structural element at the N terminus of the lambda head-tail connector protein endows it with a distinctive protein interaction capability compared with many of its putative homologues.
Phages have adapted the same protein fold to fulfill multiple functions in virion assembly.,Cardarelli L, Pell LG, Neudecker P, Pirani N, Liu A, Baker LA, Rubinstein JL, Maxwell KL, Davidson AR Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14384-9. Epub 2010 Jul 26. PMID:20660769<ref>PMID:20660769</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2kx4" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacteriophage lambda]]
[[Category: Escherichia virus Lambda]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cardarelli, L]]
[[Category: Cardarelli L]]
[[Category: Davidson, A R]]
[[Category: Davidson AR]]
[[Category: Maxwell, K L]]
[[Category: Maxwell KL]]
[[Category: Neudecker, P]]
[[Category: Neudecker P]]
[[Category: OCSP, Ontario Centre for Structural Proteomics]]
[[Category: Connector protein]]
[[Category: Gpfii]]
[[Category: Ocsp]]
[[Category: Ontario centre for structural proteomic]]
[[Category: PSI, Protein structure initiative]]
[[Category: Structural genomic]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/2kx4"