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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2l5x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L5X FirstGlance]. <br>
<table><tr><td colspan='2'>[[2l5x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L5X FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l5x OCA], [https://pdbe.org/2l5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l5x RCSB], [https://www.ebi.ac.uk/pdbsum/2l5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l5x ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l5x OCA], [https://pdbe.org/2l5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l5x RCSB], [https://www.ebi.ac.uk/pdbsum/2l5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l5x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/IL1A_HUMAN IL1A_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
[https://www.uniprot.org/uniprot/IL1A_HUMAN IL1A_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Interleukin 1alpha (IL1alpha) plays an important role in several key biological functions, such as angiogenesis, cell proliferation, and tumor growth in several types of cancer. IL1alpha is a potent cytokine that induces a wide spectrum of immunological and inflammatory activities. The biological effects of IL1alpha are mediated through the activation of transmembrane receptors (IL1Rs) and therefore require the release of the protein into the extracellular space. IL1alpha is exported through a non-classical release pathway involving the formation of a specific multiprotein complex, which includes IL1alpha and S100A13. Because IL1alpha plays an important role in cell proliferation and angiogenesis, inhibiting the formation of the IL1alpha-S100A13 complex would be an effective strategy to inhibit a wide range of cancers. To understand the molecular events in the IL1alpha release pathway, we studied the structure of the IL1alpha-S100A13 tetrameric complex, which is the key complex formed during the non-classical pathway of IL1alpha release.
The IL1alpha-S100A13 heterotetrameric complex structure: a component in the non-classical pathway for interleukin 1alpha secretion.,Mohan SK, Yu C J Biol Chem. 2011 Apr 22;286(16):14608-17. Epub 2011 Jan 26. PMID:21270123<ref>PMID:21270123</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2l5x" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Interleukin 3D structures|Interleukin 3D structures]]
*[[Interleukin 3D structures|Interleukin 3D structures]]
*[[S100 proteins 3D structures|S100 proteins 3D structures]]
*[[S100 proteins 3D structures|S100 proteins 3D structures]]
== References ==
<references/>
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__TOC__
</StructureSection>
</StructureSection>

Latest revision as of 06:53, 1 May 2024

Solution structure of IL1A-S100A13 complex

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