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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lyg OCA], [https://pdbe.org/2lyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lyg RCSB], [https://www.ebi.ac.uk/pdbsum/2lyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lyg ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lyg OCA], [https://pdbe.org/2lyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lyg RCSB], [https://www.ebi.ac.uk/pdbsum/2lyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lyg ProSAT]</span></td></tr> |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
| |
| == Publication Abstract from PubMed ==
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| Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, supramolecular chemistry to nanoscience. We have prepared carbohydrate-DNA conjugates containing the oligonucleotide sequences of G-quadruplexes (thrombin binding aptamer (TBA) and human telomere (TEL)), measured their thermal stability and studied their structure in solution by using NMR and molecular dynamics. The solution structure of a fucose-TBA conjugate shows stacking interactions between the carbohydrate and the DNA G-tetrad in addition to hydrogen bonding and hydrophobic contacts. We have also shown that attaching carbohydrates at the 5'-end of a quadruplex telomeric sequence can alter its folding topology. These results suggest the possibility of modulating the folding of the G-quadruplex by linking carbohydrates and have clear implications in molecular recognition and the design of new G-quadruplex ligands.
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| Carbohydrate-DNA interactions at G-quadruplexes: folding and stability changes by attaching sugars at the 5'-end.,Gomez-Pinto I, Vengut-Climent E, Lucas R, Avino A, Eritja R, Gonzalez C, Morales JC Chemistry. 2013 Feb 4;19(6):1920-7. doi: 10.1002/chem.201203902. Epub 2013 Jan, 11. PMID:23315826<ref>PMID:23315826</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 2lyg" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
