2lzl: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lzl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LZL FirstGlance]. <br> | <table><tr><td colspan='2'>[[2lzl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LZL FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lzl OCA], [https://pdbe.org/2lzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lzl RCSB], [https://www.ebi.ac.uk/pdbsum/2lzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lzl ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lzl OCA], [https://pdbe.org/2lzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lzl RCSB], [https://www.ebi.ac.uk/pdbsum/2lzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lzl ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/FGFR3_HUMAN FGFR3_HUMAN] Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B.<ref>PMID:8663044</ref> <ref>PMID:10611230</ref> <ref>PMID:11294897</ref> <ref>PMID:14534538</ref> <ref>PMID:16597617</ref> <ref>PMID:16410555</ref> <ref>PMID:17561467</ref> <ref>PMID:17509076</ref> <ref>PMID:17145761</ref> <ref>PMID:17311277</ref> <ref>PMID:19088846</ref> <ref>PMID:19286672</ref> | [https://www.uniprot.org/uniprot/FGFR3_HUMAN FGFR3_HUMAN] Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B.<ref>PMID:8663044</ref> <ref>PMID:10611230</ref> <ref>PMID:11294897</ref> <ref>PMID:14534538</ref> <ref>PMID:16597617</ref> <ref>PMID:16410555</ref> <ref>PMID:17561467</ref> <ref>PMID:17509076</ref> <ref>PMID:17145761</ref> <ref>PMID:17311277</ref> <ref>PMID:19088846</ref> <ref>PMID:19286672</ref> | ||
==See Also== | ==See Also== | ||
