2m1g: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1g OCA], [https://pdbe.org/2m1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m1g RCSB], [https://www.ebi.ac.uk/pdbsum/2m1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m1g ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1g OCA], [https://pdbe.org/2m1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m1g RCSB], [https://www.ebi.ac.uk/pdbsum/2m1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m1g ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Human telomeric DNA quadruplexes can adopt different conformations in solution. We have found that arabinose, 2'F-arabinose, and ribose substitutions stabilize the propeller parallel G-quadruplex form over competing conformers, allowing NMR structural determination of this particularly significant nucleic acid structure. 2'F-arabinose substitution provides the greatest stabilization as a result of electrostatic (F-CH---O4') and pseudo-hydrogen-bond (F---H8) stabilizing interactions. In contrast, 2'F-rG substitution provokes a dramatic destabilization of the quadruplex structure due to unfavorable electrostatic repulsion between the phosphate and the 2'-F.
Dramatic effect of furanose c2' substitution on structure and stability: directing the folding of the human telomeric quadruplex with a single fluorine atom.,Martin-Pintado N, Yahyaee-Anzahaee M, Deleavey GF, Portella G, Orozco M, Damha MJ, Gonzalez C J Am Chem Soc. 2013 Apr 10;135(14):5344-7. doi: 10.1021/ja401954t. Epub 2013 Mar , 27. PMID:23521511<ref>PMID:23521511</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2m1g" style="background-color:#fffaf0;"></div>
== References ==
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