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==The Three Dimensional Structure of the Moorella thermoacetica Selenocysteine Insertion Sequence RNA Hairpin and its Interaction with the Elongation factor SelB==
==The Three Dimensional Structure of the Moorella thermoacetica Selenocysteine Insertion Sequence RNA Hairpin and its Interaction with the Elongation factor SelB==
<StructureSection load='2rlu' size='340' side='right'caption='[[2rlu]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2rlu' size='340' side='right'caption='[[2rlu]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2rlu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RLU FirstGlance]. <br>
<table><tr><td colspan='2'>[[2rlu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RLU FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mfk|1mfk]], [[1wsu|1wsu]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rlu OCA], [https://pdbe.org/2rlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rlu RCSB], [https://www.ebi.ac.uk/pdbsum/2rlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rlu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rlu OCA], [https://pdbe.org/2rlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rlu RCSB], [https://www.ebi.ac.uk/pdbsum/2rlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rlu ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Incorporation of the amino acid selenocysteine into a growing protein chain involves the interaction between a hairpin in the mRNA termed the selenocysteine insertion sequence (SECIS) and the special elongation factor SelB. Here we present the structure of the SECIS from the thermophilic organism Moorella thermoacetica (SECIS-MT) determined using nuclear magnetic resonance (NMR) spectroscopy. The SECIS-MT hairpin structure contains a pentaloop with the first and fourth nucleotides of the loop forming a noncanonical GC base pair; the fifth loop nucleotide is bulged out and unstructured. The G and U in positions two and three are on opposite sides of the loop and solvent exposed. The backbone resonances of the SECIS-binding domain from the M. thermoacetica SelB protein were assigned, and the degree of chemical shift perturbations that occur upon SECIS binding were mapped onto the structure of the complex. We demonstrate that a region in the third winged-helix domain of SelB, not previously implicated in binding, is affected by SECIS binding.
The three-dimensional structure of the Moorella thermoacetica selenocysteine insertion sequence RNA hairpin and its interaction with the elongation factor SelB.,Beribisky AV, Tavares TJ, Amborski AN, Motamed M, Johnson AE, Mark TL, Johnson PE RNA. 2007 Nov;13(11):1948-56. Epub 2007 Sep 27. PMID:17901155<ref>PMID:17901155</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2rlu" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Amborski, A N]]
[[Category: Amborski AN]]
[[Category: Beribisky, A V]]
[[Category: Beribisky AV]]
[[Category: Johnson, A E]]
[[Category: Johnson AE]]
[[Category: Johnson, P E]]
[[Category: Johnson PE]]
[[Category: Mark, T L]]
[[Category: Mark TL]]
[[Category: Motamed, M]]
[[Category: Motamed M]]
[[Category: Tavares, T J]]
[[Category: Tavares TJ]]
[[Category: Protein-rna interaction]]
[[Category: Rna]]
[[Category: Rna structure]]
[[Category: Selb]]
[[Category: Selenocysteine]]

Latest revision as of 07:05, 1 May 2024

The Three Dimensional Structure of the Moorella thermoacetica Selenocysteine Insertion Sequence RNA Hairpin and its Interaction with the Elongation factor SelB

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