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==Crystal structure of the Acinetobacter baumannii outer membrane protein Omp33==
==Crystal structure of the Acinetobacter baumannii outer membrane protein Omp33==
<StructureSection load='6gie' size='340' side='right' caption='[[6gie]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='6gie' size='340' side='right'caption='[[6gie]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6gie]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GIE FirstGlance]. <br>
<table><tr><td colspan='2'>[[6gie]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GIE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gie OCA], [http://pdbe.org/6gie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gie RCSB], [http://www.ebi.ac.uk/pdbsum/6gie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gie ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6gie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gie OCA], [https://pdbe.org/6gie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6gie RCSB], [https://www.ebi.ac.uk/pdbsum/6gie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6gie ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/A0A081GU02_ACIBA A0A081GU02_ACIBA]
Acinetobacter baumannii is becoming a major threat to human health due to its multidrug resistance. This is owing in a large part to the low permeability of its outer membrane (OM), which prevents high internal antibiotic concentrations and makes antibiotic-resistance mechanisms more effective. To exploit OM channels as potential delivery vehicles for future antibiotics, structural information is required. One abundant OM protein in A. baumannii is Omp33. This protein has been reported to be important for the in vivo fitness and virulence of A. baumannii, but its structure is not known. Here, the X-ray crystal structure of Omp33 is reported at a resolution of 2.1 A. Omp33 has a 14-beta-stranded barrel without stable extracellular loop constrictions. Instead, an extended and unusual periplasmic turn connecting beta-strands 2 and 3 is present, which folds into the pore lumen and completely blocks the aqueous channel. The Omp33 structure helps in understanding how A. baumannii OM proteins contribute to the low permeability of the cell envelope of this bacterium and suggests that Omp33 might function as a gated channel.


Crystal structure of the Acinetobacter baumannii outer membrane protein Omp33.,Abellon-Ruiz J, Zahn M, Basle A, van den Berg B Acta Crystallogr D Struct Biol. 2018 Sep 1;74(Pt 9):852-860. doi:, 10.1107/S205979831800904X. Epub 2018 Sep 3. PMID:30198896<ref>PMID:30198896</ref>
==See Also==
 
*[[Porin 3D structures|Porin 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6gie" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Abellon-Ruiz, J]]
[[Category: Acinetobacter baumannii]]
[[Category: Basle, A]]
[[Category: Large Structures]]
[[Category: Berg, B van den]]
[[Category: Abellon-Ruiz J]]
[[Category: Zahn, M]]
[[Category: Basle A]]
[[Category: Channel]]
[[Category: Zahn M]]
[[Category: Membrane protein]]
[[Category: Van den Berg B]]

Latest revision as of 07:33, 1 May 2024

Crystal structure of the Acinetobacter baumannii outer membrane protein Omp33

6gie, resolution 2.10Å

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