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==DNA minidumbbell structure of two CTTG repeats==
==DNA minidumbbell structure of two CTTG repeats==
<StructureSection load='6j37' size='340' side='right'caption='[[6j37]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='6j37' size='340' side='right'caption='[[6j37]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6j37]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J37 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6J37 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6j37]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J37 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6j37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j37 OCA], [http://pdbe.org/6j37 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j37 RCSB], [http://www.ebi.ac.uk/pdbsum/6j37 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j37 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j37 OCA], [https://pdbe.org/6j37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j37 RCSB], [https://www.ebi.ac.uk/pdbsum/6j37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j37 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Minidumbbell (MDB) is a newly found non-B DNA structure formed by short single-strand sequences. Up to now, three MDBs have been reported to form at neutral pH by sequences containing two repeats of TTTA, CCTG and CTTG. Among them, the thermodynamically less stable TTTA and CCTG MDBs have been proposed to be the structural intermediates that cause TTTA and CCTG repeat expansions during DNA replication in Staphylococcus aureus pathogen and myotonic dystrophy type 2 patients, respectively. Although the CTTG MDB has a melting temperature of at least 13 degrees C higher than those of the other two, no CTTG repeat expansion has ever been reported in any genomes. In this study, we successfully determined the solution structure of the CTTG MDB and observed for the first time the formation of a reverse wobble T.T mispair with two symmetric hydrogen bonds. More importantly, we identified unprecedented hydrophobic interactions between the two methyl groups of this T.T mispair and the four 2'-methylene groups of their nearby loop-closing base pair residues. These stabilizations account for the substantial increase in the MDB thermodynamic stability which may govern the occurrence of repeat expansions. Communicated by Ramaswamy H. Sarma.
Unprecedented hydrophobic stabilizations from a reverse wobble T.T mispair in DNA minidumbbell.,Guo P, Lam SL J Biomol Struct Dyn. 2019 May 30:1-8. doi: 10.1080/07391102.2019.1621211. PMID:31107180<ref>PMID:31107180</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6j37" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Guo, P]]
[[Category: Guo P]]
[[Category: Lam, S L]]
[[Category: Lam SL]]
[[Category: Dna]]
[[Category: Hydrophobic interaction]]
[[Category: Minidumbbell]]
[[Category: Reverse wobble tt mispair]]

Latest revision as of 07:35, 1 May 2024

DNA minidumbbell structure of two CTTG repeats

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