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==Crystal structure of VP5 from Haloarchaeal pleomorphic virus 2==
==Crystal structure of VP5 from Haloarchaeal pleomorphic virus 2==
<StructureSection load='6qgi' size='340' side='right' caption='[[6qgi]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
<StructureSection load='6qgi' size='340' side='right'caption='[[6qgi]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6qgi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QGI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QGI FirstGlance]. <br>
<table><tr><td colspan='2'>[[6qgi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Halorubrum_pleomorphic_virus_2 Halorubrum pleomorphic virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QGI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qgi OCA], [http://pdbe.org/6qgi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qgi RCSB], [http://www.ebi.ac.uk/pdbsum/6qgi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qgi ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qgi OCA], [https://pdbe.org/6qgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qgi RCSB], [https://www.ebi.ac.uk/pdbsum/6qgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qgi ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/H9ABL9_9VIRU H9ABL9_9VIRU]
Lipid membrane fusion is an essential function in many biological processes. Detailed mechanisms of membrane fusion and the protein structures involved have been mainly studied in eukaryotic systems, whereas very little is known about membrane fusion in prokaryotes. Haloarchaeal pleomorphic viruses (HRPVs) have a membrane envelope decorated with spikes that are presumed to be responsible for host attachment and membrane fusion. Here we determine atomic structures of the ectodomains of the 57-kDa spike protein VP5 from two related HRPVs revealing a previously unreported V-shaped fold. By Volta phase plate cryo-electron tomography we show that VP5 is monomeric on the viral surface, and we establish the orientation of the molecules with respect to the viral membrane. We also show that the viral membrane fuses with the host cytoplasmic membrane in a process mediated by VP5. This sheds light on protein structures involved in prokaryotic membrane fusion.
 
The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins.,El Omari K, Li S, Kotecha A, Walter TS, Bignon EA, Harlos K, Somerharju P, De Haas F, Clare DK, Molin M, Hurtado F, Li M, Grimes JM, Bamford DH, Tischler ND, Huiskonen JT, Stuart DI, Roine E Nat Commun. 2019 Feb 19;10(1):846. doi: 10.1038/s41467-019-08728-7. PMID:30783086<ref>PMID:30783086</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6qgi" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Grimes, J M]]
[[Category: Halorubrum pleomorphic virus 2]]
[[Category: Harlos, K]]
[[Category: Large Structures]]
[[Category: Omari, K El]]
[[Category: El Omari K]]
[[Category: Roine, E]]
[[Category: Grimes JM]]
[[Category: Stuart, D I]]
[[Category: Harlos K]]
[[Category: Walter, T S]]
[[Category: Roine E]]
[[Category: Membrane fusion]]
[[Category: Stuart DI]]
[[Category: Prokaryotic]]
[[Category: Walter TS]]
[[Category: Viral]]
[[Category: Viral protein]]

Revision as of 07:37, 1 May 2024

Crystal structure of VP5 from Haloarchaeal pleomorphic virus 2

6qgi, resolution 2.46Å

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