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====
==Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Post-A1==
<StructureSection load='6zqd' size='340' side='right'caption='[[6zqd]]' scene=''>
<StructureSection load='6zqd' size='340' side='right'caption='[[6zqd]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
<table><tr><td colspan='2'>[[6zqd]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZQD FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6zqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zqd OCA], [http://pdbe.org/6zqd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6zqd RCSB], [http://www.ebi.ac.uk/pdbsum/6zqd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6zqd ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zqd OCA], [https://pdbe.org/6zqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zqd RCSB], [https://www.ebi.ac.uk/pdbsum/6zqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zqd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UTP8_YEAST UTP8_YEAST] Involved in nucleolar processing of pre-18S ribosomal RNA. Also has a role in nuclear tRNA export. It acts between the steps of tRNA maturation/aminoacylation and its subsequent translocation out of the nucleus. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).<ref>PMID:12068309</ref> <ref>PMID:12794079</ref> <ref>PMID:15489292</ref>
==See Also==
*[[Adenosine dimethyltransferase 3D structures|Adenosine dimethyltransferase 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome biogenesis protein 3D structures|Ribosome biogenesis protein 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Z-disk]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Beckmann R]]
[[Category: Berninghausen O]]
[[Category: Cheng J]]
[[Category: Hurt E]]
[[Category: Lau B]]
[[Category: Venuta GL]]
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