1t0y: Difference between revisions

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==Solution Structure of a Ubiquitin-Like Domain from Tubulin-binding Cofactor B==
==Solution Structure of a Ubiquitin-Like Domain from Tubulin-binding Cofactor B==
<StructureSection load='1t0y' size='340' side='right'caption='[[1t0y]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1t0y' size='340' side='right'caption='[[1t0y]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1t0y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caeel Caeel]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T0Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[1t0y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T0Y FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lpl|1lpl]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">5O73 or F53F4.3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t0y OCA], [https://pdbe.org/1t0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t0y RCSB], [https://www.ebi.ac.uk/pdbsum/1t0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t0y ProSAT], [https://www.topsan.org/Proteins/SECSG/1t0y TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t0y OCA], [https://pdbe.org/1t0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t0y RCSB], [https://www.ebi.ac.uk/pdbsum/1t0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t0y ProSAT], [https://www.topsan.org/Proteins/SECSG/1t0y TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TBCB_CAEEL TBCB_CAEEL]] Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer.  
[https://www.uniprot.org/uniprot/TBCB_CAEEL TBCB_CAEEL] Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t0y ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t0y ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Proper folding and assembly of tubulin alphabeta-heterodimers involves a stepwise progression mediated by a group of protein cofactors A through E. Upon release of the tubulin monomers from the chaperonin CCT, they are acted upon by each cofactor in the folding pathway through a unique combination of protein interaction domains. Three-dimensional structures have previously been reported for cofactor A and the C-terminal CAP-Gly domain of cofactor B (CoB). Here we report the NMR structure of the N-terminal domain of Caenorhabditis elegans CoB and show that it closely resembles ubiquitin as was recently postulated on the basis of bioinformatic analysis (Grynberg, M., Jaroszewski, L., and Godzik, A. (2003) BMC Bioinformatics 4, 46). CoB binds partially folded alpha-tubulin monomers, and a putative tubulin-binding motif within the N-terminal domain is identified from sequence and structure comparisons. Based on modeling of the homologous cofactor E ubiquitin-like domain, we hypothesize that cofactors B and E may associate via their beta-grasp domains in a manner analogous to the PB1 and caspase-activated deoxyribonuclease superfamily of protein interaction domains.
Solution structure of a ubiquitin-like domain from tubulin-binding cofactor B.,Lytle BL, Peterson FC, Qiu SH, Luo M, Zhao Q, Markley JL, Volkman BF J Biol Chem. 2004 Nov 5;279(45):46787-93. Epub 2004 Sep 9. PMID:15364906<ref>PMID:15364906</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1t0y" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Caeel]]
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Luo M]]
[[Category: Luo, M]]
[[Category: Lytle BL]]
[[Category: Lytle, B L]]
[[Category: Markley JL]]
[[Category: Markley, J L]]
[[Category: Peterson FC]]
[[Category: Peterson, F C]]
[[Category: Qui SH]]
[[Category: Qui, S H]]
[[Category: Volkman BF]]
[[Category: Volkman, B F]]
[[Category: Cesg]]
[[Category: Chaperone]]
[[Category: Cytoskeleton]]
[[Category: Microtubule]]
[[Category: PSI, Protein structure initiative]]
[[Category: Tubulin]]
[[Category: Ubiquitin-like]]
Retrieved from "https://proteopedia.org/1t0y"