8v9b: Difference between revisions

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'''Unreleased structure'''


The entry 8v9b is ON HOLD  until Paper Publication
==Lipoprotein(a) Kringle IV domain 7 - Lp(a) KIV7 in complex with LY3441732==
 
<StructureSection load='8v9b' size='340' side='right'caption='[[8v9b]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
Authors: Hendle, J., Weichert, K., Sauder, J.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8v9b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V9B FirstGlance]. <br>
Description: Lipoprotein(a) Kringle IV domain 7 -Lp(a) KIV7 in complex with LY3441732
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.19&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AAM:(2S,2S)-3,3-[carbonylbis(azanediyl-3,1-phenylene)]bis{2-[(3R)-pyrrolidin-1-ium-3-yl]propanoate}'>A1AAM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Hendle, J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v9b OCA], [https://pdbe.org/8v9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v9b RCSB], [https://www.ebi.ac.uk/pdbsum/8v9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v9b ProSAT]</span></td></tr>
[[Category: Sauder, J.M]]
</table>
[[Category: Weichert, K]]
== Function ==
[https://www.uniprot.org/uniprot/APOA_HUMAN APOA_HUMAN] Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.<ref>PMID:2531657</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hendle J]]
[[Category: Sauder JM]]
[[Category: Weichert K]]
Retrieved from "https://proteopedia.org/8v9b"