1w0e: Difference between revisions

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<StructureSection load='1w0e' size='340' side='right'caption='[[1w0e]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='1w0e' size='340' side='right'caption='[[1w0e]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1w0e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. The October 2006 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Cytochrome p450''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2006_10 10.2210/rcsb_pdb/mom_2006_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W0E FirstGlance]. <br>
<table><tr><td colspan='2'>[[1w0e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The October 2006 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Cytochrome p450''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2006_10 10.2210/rcsb_pdb/mom_2006_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W0E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w0f|1w0f]], [[1w0g|1w0g]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0e OCA], [https://pdbe.org/1w0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w0e RCSB], [https://www.ebi.ac.uk/pdbsum/1w0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w0e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0e OCA], [https://pdbe.org/1w0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w0e RCSB], [https://www.ebi.ac.uk/pdbsum/1w0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w0e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Cytochrome p450]]
[[Category: Cytochrome p450]]
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Angove, H C]]
[[Category: Angove HC]]
[[Category: Cosme, J]]
[[Category: Cosme J]]
[[Category: Day, P J]]
[[Category: Day PJ]]
[[Category: Jhoti, H]]
[[Category: Jhoti H]]
[[Category: Tickle, I J]]
[[Category: Tickle IJ]]
[[Category: Vinkovic, D M]]
[[Category: Vinkovic DM]]
[[Category: Vonrhein, C]]
[[Category: Vonrhein C]]
[[Category: Ward, A]]
[[Category: Ward A]]
[[Category: Williams, P A]]
[[Category: Williams PA]]
[[Category: Electron transport]]
[[Category: Monooxygenase]]
[[Category: Nifedipine oxidase]]
[[Category: Oxidoreductase]]
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