2blc: Difference between revisions

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<StructureSection load='2blc' size='340' side='right'caption='[[2blc]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='2blc' size='340' side='right'caption='[[2blc]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2blc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BLC FirstGlance]. <br>
<table><tr><td colspan='2'>[[2blc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BLC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP7:6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE'>CP7</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bl9|2bl9]], [[2bla|2bla]], [[2blb|2blb]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP7:6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE'>CP7</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2blc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2blc OCA], [https://pdbe.org/2blc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2blc RCSB], [https://www.ebi.ac.uk/pdbsum/2blc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2blc ProSAT], [https://www.topsan.org/Proteins/RSGI/2blc TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2blc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2blc OCA], [https://pdbe.org/2blc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2blc RCSB], [https://www.ebi.ac.uk/pdbsum/2blc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2blc ProSAT], [https://www.topsan.org/Proteins/RSGI/2blc TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DRTS_PLAVI DRTS_PLAVI] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dihydrofolate reductase]]
[[Category: Haemamoeba vivax]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chitnumsub, P]]
[[Category: Khongsuk, P]]
[[Category: Kongsaeree, P]]
[[Category: Leartsakulpanich, U]]
[[Category: Tarnchompoo, B]]
[[Category: Walkinshaw, M D]]
[[Category: Yuthavong, Y]]
[[Category: Double mutant]]
[[Category: Drug resistance]]
[[Category: Malaria]]
[[Category: Oxidoreductase]]
[[Category: Plasmodium vivax]]
[[Category: Plasmodium vivax]]
[[Category: Pyrimethamine]]
[[Category: Chitnumsub P]]
[[Category: Thymidylate synthase]]
[[Category: Khongsuk P]]
[[Category: Kongsaeree P]]
[[Category: Leartsakulpanich U]]
[[Category: Tarnchompoo B]]
[[Category: Walkinshaw MD]]
[[Category: Yuthavong Y]]
Retrieved from "https://proteopedia.org/2blc"