2bo4: Difference between revisions

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<StructureSection load='2bo4' size='340' side='right'caption='[[2bo4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='2bo4' size='340' side='right'caption='[[2bo4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2bo4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43812 Atcc 43812]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BO4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2bo4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodothermus_marinus Rhodothermus marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BO4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bo6|2bo6]], [[2bo7|2bo7]], [[2bo8|2bo8]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bo4 OCA], [https://pdbe.org/2bo4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bo4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bo4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bo4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bo4 OCA], [https://pdbe.org/2bo4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bo4 RCSB], [https://www.ebi.ac.uk/pdbsum/2bo4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bo4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/MGS_RHOMR MGS_RHOMR]] Involved in the biosynthesis of the stress protectant 2-O-alpha-D-mannosyl glycerate (MG) which is produced in response to growth at supraoptimal temperature and salinity, and protects several enzymes against inactivation by temperature, freeze-drying and osmotic stress. Catalyzes the condensation of alpha-GDP-D-mannose (GDP-Man) with D-glycerate to produce alpha-mannosyl-D-glycerate. It is specific for GDP-Man, but it can also use alpha-GDP-D-glucose (GDP-Glc), beta-GDP-D-fuctose, alpha-UDP-D-mannose and alpha-UDP-D-glucose as sugar donors. It is specific for D-glycerate, but it can also use D-lactate and glycolate as sugar acceptors. This reaction occurs with a net retention of anomeric configuration; the newly formed glycosidic linkage has the same alpha configuration as the sugar donor.<ref>PMID:10585410</ref> <ref>PMID:15951819</ref> <ref>PMID:21288903</ref>
[https://www.uniprot.org/uniprot/MGS_RHOMR MGS_RHOMR] Involved in the biosynthesis of the stress protectant 2-O-alpha-D-mannosyl glycerate (MG) which is produced in response to growth at supraoptimal temperature and salinity, and protects several enzymes against inactivation by temperature, freeze-drying and osmotic stress. Catalyzes the condensation of alpha-GDP-D-mannose (GDP-Man) with D-glycerate to produce alpha-mannosyl-D-glycerate. It is specific for GDP-Man, but it can also use alpha-GDP-D-glucose (GDP-Glc), beta-GDP-D-fuctose, alpha-UDP-D-mannose and alpha-UDP-D-glucose as sugar donors. It is specific for D-glycerate, but it can also use D-lactate and glycolate as sugar acceptors. This reaction occurs with a net retention of anomeric configuration; the newly formed glycosidic linkage has the same alpha configuration as the sugar donor.<ref>PMID:10585410</ref> <ref>PMID:15951819</ref> <ref>PMID:21288903</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 43812]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bolam, D N]]
[[Category: Rhodothermus marinus]]
[[Category: Davies, G J]]
[[Category: Bolam DN]]
[[Category: Davis, B G]]
[[Category: Davies GJ]]
[[Category: Dodson, E J]]
[[Category: Davis BG]]
[[Category: Flint, J]]
[[Category: Dodson EJ]]
[[Category: Gilbert, H J]]
[[Category: Flint J]]
[[Category: Martinez-Fleites, C]]
[[Category: Gilbert HJ]]
[[Category: Tailford, L E]]
[[Category: Martinez-Fleites C]]
[[Category: Taylor, E]]
[[Category: Tailford LE]]
[[Category: Yang, M]]
[[Category: Taylor E]]
[[Category: Catalysis]]
[[Category: Yang M]]
[[Category: Glycosyltransferase]]
[[Category: Mannose]]
[[Category: Stereoselectivity]]
[[Category: Transferase]]
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