2cjs: Difference between revisions

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<StructureSection load='2cjs' size='340' side='right'caption='[[2cjs]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
<StructureSection load='2cjs' size='340' side='right'caption='[[2cjs]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2cjs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2CJS FirstGlance]. <br>
<table><tr><td colspan='2'>[[2cjs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CJS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y8f|1y8f]], [[2a20|2a20]], [[2bwq|2bwq]], [[2cjt|2cjt]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2cjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjs OCA], [http://pdbe.org/2cjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cjs RCSB], [http://www.ebi.ac.uk/pdbsum/2cjs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjs OCA], [https://pdbe.org/2cjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cjs RCSB], [https://www.ebi.ac.uk/pdbsum/2cjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UN13A_RAT UN13A_RAT] Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Also involved in secretory granule priming in insulin secretion.<ref>PMID:9697857</ref> <ref>PMID:11343654</ref> <ref>PMID:11792326</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Dai, H]]
[[Category: Rattus norvegicus]]
[[Category: Dulubova, I]]
[[Category: Dai H]]
[[Category: Lu, J]]
[[Category: Dulubova I]]
[[Category: Machius, M]]
[[Category: Lu J]]
[[Category: Rizo, J]]
[[Category: Machius M]]
[[Category: Sudhof, T C]]
[[Category: Rizo J]]
[[Category: Tomchick, D R]]
[[Category: Sudhof TC]]
[[Category: C2 domain]]
[[Category: Tomchick DR]]
[[Category: Exocytosis]]
[[Category: Metal-binding]]
[[Category: Munc13]]
[[Category: Neurotransmitter release]]
[[Category: Neurotransmitter transport]]
[[Category: Phorbol-ester binding]]
[[Category: Protein- protein interaction]]
[[Category: Rim]]
[[Category: Synapse]]
[[Category: Synaptosome]]
[[Category: Transport]]
[[Category: Zinc finger]]
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