2v6f: Difference between revisions

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<StructureSection load='2v6f' size='340' side='right'caption='[[2v6f]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2v6f' size='340' side='right'caption='[[2v6f]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2v6f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Digla Digla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V6F FirstGlance]. <br>
<table><tr><td colspan='2'>[[2v6f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Digitalis_lanata Digitalis lanata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V6F FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v6g|2v6g]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v6f OCA], [https://pdbe.org/2v6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v6f RCSB], [https://www.ebi.ac.uk/pdbsum/2v6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v6f ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v6f OCA], [https://pdbe.org/2v6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v6f RCSB], [https://www.ebi.ac.uk/pdbsum/2v6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v6f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/5BPOR_DIGLA 5BPOR_DIGLA]] Involved in cardenolide biosynthesis. Catalyzes the stereospecific conversion of progesterone to 5-beta-pregnane-3,20-dione. Can use progesterone, testosterone, 4-androstene-3,17-dione, cortisol and cortisone as substrates, but not pregnenolone, 21-OH-pregnenolone or isoprogesterone. NADPH could not be replaced by NADH.<ref>PMID:16386278</ref> <ref>PMID:18032383</ref>
[https://www.uniprot.org/uniprot/5BPOR_DIGLA 5BPOR_DIGLA] Involved in cardenolide biosynthesis. Catalyzes the stereospecific conversion of progesterone to 5-beta-pregnane-3,20-dione. Can use progesterone, testosterone, 4-androstene-3,17-dione, cortisol and cortisone as substrates, but not pregnenolone, 21-OH-pregnenolone or isoprogesterone. NADPH could not be replaced by NADH.<ref>PMID:16386278</ref> <ref>PMID:18032383</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Digla]]
[[Category: Digitalis lanata]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Egerer-Sieber, C]]
[[Category: Egerer-Sieber C]]
[[Category: Herl, V]]
[[Category: Herl V]]
[[Category: Jaeger, C M]]
[[Category: Jaeger CM]]
[[Category: Kreis, W]]
[[Category: Kreis W]]
[[Category: Mueller-Uri, F]]
[[Category: Mueller-Uri F]]
[[Category: Muller, Y A]]
[[Category: Muller YA]]
[[Category: Thorn, A]]
[[Category: Thorn A]]
[[Category: Cardenolide]]
[[Category: Cardiac glycoside]]
[[Category: Oxidoreductase]]
[[Category: Reductase]]
[[Category: Sdr]]
[[Category: Tyrosine-dependent oxidoreductase]]
Retrieved from "https://proteopedia.org/2v6f"