2vd3: Difference between revisions

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<StructureSection load='2vd3' size='340' side='right'caption='[[2vd3]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='2vd3' size='340' side='right'caption='[[2vd3]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vd3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Metth Metth]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VD3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vd3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._Delta_H Methanothermobacter thermautotrophicus str. Delta H]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VD3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ATP_phosphoribosyltransferase ATP phosphoribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.17 2.4.2.17] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd3 OCA], [https://pdbe.org/2vd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vd3 RCSB], [https://www.ebi.ac.uk/pdbsum/2vd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vd3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vd3 OCA], [https://pdbe.org/2vd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vd3 RCSB], [https://www.ebi.ac.uk/pdbsum/2vd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vd3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HIS1_METTH HIS1_METTH] Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: ATP phosphoribosyltransferase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Metth]]
[[Category: Methanothermobacter thermautotrophicus str. Delta H]]
[[Category: Lapthorn, A J]]
[[Category: Lapthorn AJ]]
[[Category: Lohkamp, B]]
[[Category: Lohkamp B]]
[[Category: Schweikert, T]]
[[Category: Schweikert T]]
[[Category: Amino-acid biosynthesis]]
[[Category: Atp phosphoribosyl transferase]]
[[Category: Glycosyltransferase]]
[[Category: Hisg]]
[[Category: Histidine]]
[[Category: Histidine biosynthesis]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2vd3"