2voe: Difference between revisions

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<StructureSection load='2voe' size='340' side='right'caption='[[2voe]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2voe' size='340' side='right'caption='[[2voe]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2voe]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOE FirstGlance]. <br>
<table><tr><td colspan='2'>[[2voe]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOE FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vhv|2vhv]], [[2vhw|2vhw]], [[2vhx|2vhx]], [[2vhy|2vhy]], [[2vhz|2vhz]], [[2voj|2voj]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alanine_dehydrogenase Alanine dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.1.1 1.4.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2voe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voe OCA], [https://pdbe.org/2voe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2voe RCSB], [https://www.ebi.ac.uk/pdbsum/2voe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2voe ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2voe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voe OCA], [https://pdbe.org/2voe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2voe RCSB], [https://www.ebi.ac.uk/pdbsum/2voe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2voe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DHA_MYCTU DHA_MYCTU]] Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.<ref>PMID:10527947</ref>
[https://www.uniprot.org/uniprot/DHA_MYCTU DHA_MYCTU] Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.<ref>PMID:10527947</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Alanine dehydrogenase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Ramachandran, R]]
[[Category: Ramachandran R]]
[[Category: Tripathi, S M]]
[[Category: Tripathi SM]]
[[Category: Nad]]
[[Category: Oxidoreductase]]
[[Category: Pyruvate]]
[[Category: Secreted]]
Retrieved from "https://proteopedia.org/2voe"