2wqi: Difference between revisions

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<StructureSection load='2wqi' size='340' side='right'caption='[[2wqi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='2wqi' size='340' side='right'caption='[[2wqi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wqi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQI FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wqi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQI FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dxs|1dxs]], [[2wqj|2wqj]], [[2wtt|2wtt]], [[1cok|1cok]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqi OCA], [https://pdbe.org/2wqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wqi RCSB], [https://www.ebi.ac.uk/pdbsum/2wqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqi OCA], [https://pdbe.org/2wqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wqi RCSB], [https://www.ebi.ac.uk/pdbsum/2wqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Joerger, A C]]
[[Category: Joerger AC]]
[[Category: Apoptosis]]
[[Category: Cell cycle]]
[[Category: Cell-cycle control]]
[[Category: Cooperativity]]
[[Category: Development]]
[[Category: Dna-binding]]
[[Category: Oligomerization domain]]
[[Category: P53]]
[[Category: P63]]
[[Category: P73]]
[[Category: Tetramer]]
[[Category: Transcription]]
[[Category: Transcription factor]]
[[Category: Transcription regulation]]
[[Category: Tumor suppression]]
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