4a4i: Difference between revisions

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<StructureSection load='4a4i' size='340' side='right'caption='[[4a4i]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4a4i' size='340' side='right'caption='[[4a4i]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4a4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A4I FirstGlance]. <br>
<table><tr><td colspan='2'>[[4a4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A4I FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4a65|4a65]], [[4a76|4a76]], [[4alp|4alp]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4i OCA], [https://pdbe.org/4a4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a4i RCSB], [https://www.ebi.ac.uk/pdbsum/4a4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a4i ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4i OCA], [https://pdbe.org/4a4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a4i RCSB], [https://www.ebi.ac.uk/pdbsum/4a4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a4i ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/LN28B_HUMAN LN28B_HUMAN]] Neuroblastoma.
[https://www.uniprot.org/uniprot/LN28B_HUMAN LN28B_HUMAN] Neuroblastoma.  
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/LN28B_HUMAN LN28B_HUMAN]] Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.<ref>PMID:16971064</ref> <ref>PMID:18951094</ref> <ref>PMID:19703396</ref>
[https://www.uniprot.org/uniprot/LN28B_HUMAN LN28B_HUMAN] Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.<ref>PMID:16971064</ref> <ref>PMID:18951094</ref> <ref>PMID:19703396</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Doege, N]]
[[Category: Doege N]]
[[Category: Heinemann, U]]
[[Category: Heinemann U]]
[[Category: Mayr, F]]
[[Category: Mayr F]]
[[Category: Schuetz, A]]
[[Category: Schuetz A]]
[[Category: Rna binding protein]]
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