4b7p: Difference between revisions

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<StructureSection load='4b7p' size='340' side='right'caption='[[4b7p]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4b7p' size='340' side='right'caption='[[4b7p]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4b7p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7P FirstGlance]. <br>
<table><tr><td colspan='2'>[[4b7p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7P FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9UN:5-[2,4-DIHYDROXY-6-(4-NITROPHENOXY)PHENYL]-N-(1-METHYLPIPERIDIN-4-YL)-1,2-OXAZOLE-3-CARBOXAMIDE'>9UN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1byq|1byq]], [[1osf|1osf]], [[1uy6|1uy6]], [[1uy7|1uy7]], [[1uy8|1uy8]], [[1uy9|1uy9]], [[1uyc|1uyc]], [[1uyd|1uyd]], [[1uye|1uye]], [[1uyf|1uyf]], [[1uyg|1uyg]], [[1uyh|1uyh]], [[1uyi|1uyi]], [[1uyk|1uyk]], [[1uyl|1uyl]], [[1yc1|1yc1]], [[1yc3|1yc3]], [[1yc4|1yc4]], [[1yer|1yer]], [[1yes|1yes]], [[1yet|1yet]], [[2bsm|2bsm]], [[2bt0|2bt0]], [[2bug|2bug]], [[2byh|2byh]], [[2byi|2byi]], [[2bz5|2bz5]], [[2c2l|2c2l]], [[2ccs|2ccs]], [[2cct|2cct]], [[2ccu|2ccu]], [[2fwy|2fwy]], [[2fwz|2fwz]], [[2jjc|2jjc]], [[2uwd|2uwd]], [[2vci|2vci]], [[2vcj|2vcj]], [[2wi1|2wi1]], [[2wi2|2wi2]], [[2wi3|2wi3]], [[2wi4|2wi4]], [[2wi5|2wi5]], [[2wi6|2wi6]], [[2wi7|2wi7]], [[2xab|2xab]], [[2xdk|2xdk]], [[2xdl|2xdl]], [[2xds|2xds]], [[2xdu|2xdu]], [[2xdx|2xdx]], [[2xhr|2xhr]], [[2xht|2xht]], [[2xhx|2xhx]], [[2xjg|2xjg]], [[2xjj|2xjj]], [[2xjx|2xjx]], [[2xk2|2xk2]], [[2ye2|2ye2]], [[2ye3|2ye3]], [[2ye4|2ye4]], [[2ye5|2ye5]], [[2ye6|2ye6]], [[2ye7|2ye7]], [[2ye8|2ye8]], [[2ye9|2ye9]], [[2yea|2yea]], [[2yeb|2yeb]], [[2yec|2yec]], [[2yed|2yed]], [[2yee|2yee]], [[2yef|2yef]], [[2yeg|2yeg]], [[2yeh|2yeh]], [[2yei|2yei]], [[2yej|2yej]], [[2yi0|2yi0]], [[2yi5|2yi5]], [[2yi6|2yi6]], [[2yi7|2yi7]], [[2yjw|2yjw]], [[2yjx|2yjx]], [[2yk2|2yk2]], [[2yk9|2yk9]], [[2ykb|2ykb]], [[2ykc|2ykc]], [[2yke|2yke]], [[2yki|2yki]], [[2ykj|2ykj]], [[4aif|4aif]], [[4awo|4awo]], [[4awp|4awp]], [[4awq|4awq]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9UN:5-[2,4-DIHYDROXY-6-(4-NITROPHENOXY)PHENYL]-N-(1-METHYLPIPERIDIN-4-YL)-1,2-OXAZOLE-3-CARBOXAMIDE'>9UN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7p OCA], [https://pdbe.org/4b7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7p RCSB], [https://www.ebi.ac.uk/pdbsum/4b7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7p OCA], [https://pdbe.org/4b7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7p RCSB], [https://www.ebi.ac.uk/pdbsum/4b7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ballinari, D]]
[[Category: Ballinari D]]
[[Category: Brasca, M G]]
[[Category: Brasca MG]]
[[Category: Casale, E]]
[[Category: Casale E]]
[[Category: Ciomei, M]]
[[Category: Ciomei M]]
[[Category: Degrassi, A]]
[[Category: De Ponti A]]
[[Category: Donati, D]]
[[Category: Degrassi A]]
[[Category: Felder, E]]
[[Category: Donati D]]
[[Category: Fogliatto, G]]
[[Category: Felder E]]
[[Category: Galvani, A]]
[[Category: Fogliatto G]]
[[Category: Germani, M]]
[[Category: Galvani A]]
[[Category: Gianellini, L]]
[[Category: Germani M]]
[[Category: Guanci, M]]
[[Category: Gianellini L]]
[[Category: Isacchi, A]]
[[Category: Guanci M]]
[[Category: Mantegani, S]]
[[Category: Isacchi A]]
[[Category: Paolucci, M]]
[[Category: Mantegani S]]
[[Category: Pesenti, E]]
[[Category: Paolucci M]]
[[Category: Polucci, P]]
[[Category: Pesenti E]]
[[Category: Ponti, A De]]
[[Category: Polucci P]]
[[Category: Russo, M]]
[[Category: Russo M]]
[[Category: Sola, F]]
[[Category: Sola F]]
[[Category: Valsasina, B]]
[[Category: Valsasina B]]
[[Category: Visco, C]]
[[Category: Visco C]]
[[Category: Zuccotto, F]]
[[Category: Zuccotto F]]
[[Category: Atp-binding]]
[[Category: Atpase]]
[[Category: Chaperone]]
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