4bbx: Difference between revisions
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<StructureSection load='4bbx' size='340' side='right'caption='[[4bbx]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='4bbx' size='340' side='right'caption='[[4bbx]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4bbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BBX FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LKF:4-[3-[1-[(2S)-2-METHOXYPROPYL]PYRAZOL-4-YL]-2-METHYL-IMIDAZO[1,2-A]PYRAZIN-8-YL]MORPHOLINE'>LKF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LKF:4-[3-[1-[(2S)-2-METHOXYPROPYL]PYRAZOL-4-YL]-2-METHYL-IMIDAZO[1,2-A]PYRAZIN-8-YL]MORPHOLINE'>LKF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbx OCA], [https://pdbe.org/4bbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bbx RCSB], [https://www.ebi.ac.uk/pdbsum/4bbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bbx ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbx OCA], [https://pdbe.org/4bbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bbx RCSB], [https://www.ebi.ac.uk/pdbsum/4bbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bbx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bartolome-Nebreda | [[Category: Bartolome-Nebreda JM]] | ||
[[Category: Conde-Ceide | [[Category: Conde-Ceide S]] | ||
[[Category: Delgado | [[Category: Delgado F]] | ||
[[Category: Iturrino | [[Category: Iturrino L]] | ||
[[Category: Langlois | [[Category: Langlois X]] | ||
[[Category: Macdonald | [[Category: Macdonald GJ]] | ||
[[Category: Martin | [[Category: Martin ML]] | ||
[[Category: Martinez-Viturro | [[Category: Martinez-Viturro CM]] | ||
[[Category: Megens | [[Category: Megens A]] | ||
[[Category: Pastor | [[Category: Pastor J]] | ||
[[Category: Sanderson | [[Category: Sanderson W]] | ||
[[Category: Somers | [[Category: Somers M]] | ||
[[Category: Tong | [[Category: Tong HM]] | ||
[[Category: Vanhoof | [[Category: Vanhoof G]] | ||
Latest revision as of 10:59, 9 May 2024
Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia
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