6fl4: Difference between revisions
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<StructureSection load='6fl4' size='340' side='right'caption='[[6fl4]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='6fl4' size='340' side='right'caption='[[6fl4]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6fl4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[6fl4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FL4 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8DG:8-OXO-2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>8DG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fl4 OCA], [https://pdbe.org/6fl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fl4 RCSB], [https://www.ebi.ac.uk/pdbsum/6fl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fl4 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fl4 OCA], [https://pdbe.org/6fl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fl4 RCSB], [https://www.ebi.ac.uk/pdbsum/6fl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fl4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/NUDT1_ARATH NUDT1_ARATH] Mediates the hydrolysis of some nucleoside diphosphate derivatives. Its substrate specificity is unclear. In vitro, it can use NTP, dNTP, 8-oxo-GTP, 8-oxo-dGTP, dGTP, dATP, dTTP or dihydroneopterin triphosphate (DHNTP) as substrate. Has some NADH pyrophosphatase activity in vitro; however, such activity may not be relevant in vivo due to the high concentration of manganese used during the experiments. Plays an important role in protection against oxidative DNA and RNA damage by removing oxidatively damaged form of guanine.<ref>PMID:15611104</ref> <ref>PMID:15878881</ref> <ref>PMID:17804481</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Arabidopsis thaliana]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Carter | [[Category: Carter M]] | ||
[[Category: Helleday | [[Category: Helleday T]] | ||
[[Category: Jemth | [[Category: Jemth AS]] | ||
[[Category: Scaletti-Hutchinson | [[Category: Scaletti-Hutchinson E]] | ||
[[Category: Stenmark | [[Category: Stenmark P]] | ||
Latest revision as of 12:29, 9 May 2024
A. thaliana NUDT1 in complex with 8-oxo-dGTP
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