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==Structure of the PRO-PRO endopeptidase (PPEP-2) from Paenibacillus alvei==
==Structure of the PRO-PRO endopeptidase (PPEP-2) from Paenibacillus alvei==
<StructureSection load='6fpc' size='340' side='right' caption='[[6fpc]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='6fpc' size='340' side='right'caption='[[6fpc]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fpc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_6344 Atcc 6344]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FPC FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fpc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Paenibacillus_alvei Paenibacillus alvei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FPC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PAV_1c07830 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44250 ATCC 6344])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pro-Pro_endopeptidase Pro-Pro endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.89 3.4.24.89] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fpc OCA], [https://pdbe.org/6fpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fpc RCSB], [https://www.ebi.ac.uk/pdbsum/6fpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fpc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fpc OCA], [http://pdbe.org/6fpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fpc RCSB], [http://www.ebi.ac.uk/pdbsum/6fpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fpc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PPEP2_PAEA2 PPEP2_PAEA2] Zinc-dependent endoprotease with a unique preference for proline residues surrounding the scissile bond, which cleaves in a PLP-|-PVP motif. Cleaves the cell surface protein encoded by an adjacent gene, which contains two PPEP-2 cleaving sites and putative extracellular matrix-binding domains. Thereby, may have a role in the regulation of P.alvei adhesion. Is not able to cleave within the PVP-|-PVQ motif, and only shows a very poor cleavage of the VNP-|-PVP motif in vitro, which is the optimal substrate peptide for PPEP-1 from P.difficile.<ref>PMID:29794027</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 6344]]
[[Category: Large Structures]]
[[Category: Pro-Pro endopeptidase]]
[[Category: Paenibacillus alvei]]
[[Category: Hensbergen, P J]]
[[Category: Hensbergen PJ]]
[[Category: Klychnikov, O I]]
[[Category: Klychnikov OI]]
[[Category: Strelkov, S V]]
[[Category: Strelkov SV]]
[[Category: Weeks, S D]]
[[Category: Weeks SD]]
[[Category: Endopeptidase]]
[[Category: Hydrolase]]
[[Category: Metalloprotease]]
[[Category: Zinc]]
Retrieved from "https://proteopedia.org/6fpc"