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==Structure of S. pombe Mmi1 in complex with 11-mer RNA==
==Structure of S. pombe Mmi1 in complex with 11-mer RNA==
<StructureSection load='6fpx' size='340' side='right' caption='[[6fpx]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
<StructureSection load='6fpx' size='340' side='right'caption='[[6fpx]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fpx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FPX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FPX FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fpx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FPX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mmi1, SPCC736.12c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fpx OCA], [http://pdbe.org/6fpx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fpx RCSB], [http://www.ebi.ac.uk/pdbsum/6fpx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fpx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fpx OCA], [https://pdbe.org/6fpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fpx RCSB], [https://www.ebi.ac.uk/pdbsum/6fpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fpx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MMI1_SCHPO MMI1_SCHPO]] RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (By similarity). Required for elemination of certain meiosis-specific mRNAs in an early event following transcription. May bind to the cis-acting region (DSR) of the mRNA, activating the nuclear exosome which may lead to the degradation of the transcript from the 3' region (PubMed:16823445).[UniProtKB:Q06390]<ref>PMID:16823445</ref>
[https://www.uniprot.org/uniprot/MMI1_SCHPO MMI1_SCHPO] RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (By similarity). Required for elemination of certain meiosis-specific mRNAs in an early event following transcription. May bind to the cis-acting region (DSR) of the mRNA, activating the nuclear exosome which may lead to the degradation of the transcript from the 3' region (PubMed:16823445).[UniProtKB:Q06390]<ref>PMID:16823445</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cbs 356]]
[[Category: Large Structures]]
[[Category: Freund, S M.V]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Hill, C H]]
[[Category: Freund SMV]]
[[Category: McLaughlin, S H]]
[[Category: Hill CH]]
[[Category: Passmore, L A]]
[[Category: McLaughlin SH]]
[[Category: Stowell, J A.W]]
[[Category: Passmore LA]]
[[Category: Wagstaff, J L]]
[[Category: Stowell JAW]]
[[Category: Yu, M]]
[[Category: Wagstaff JL]]
[[Category: Meiosis mrna decay]]
[[Category: Yu M]]
[[Category: Rna binding protein]]
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