1whc: Difference between revisions
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==Solution Structure of RSGI RUH-027, a UBA domain from Mouse cDNA== | ==Solution Structure of RSGI RUH-027, a UBA domain from Mouse cDNA== | ||
<StructureSection load='1whc' size='340' side='right'caption='[[1whc | <StructureSection load='1whc' size='340' side='right'caption='[[1whc]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1whc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1whc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHC FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whc OCA], [https://pdbe.org/1whc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whc RCSB], [https://www.ebi.ac.uk/pdbsum/1whc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whc ProSAT], [https://www.topsan.org/Proteins/RSGI/1whc TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whc OCA], [https://pdbe.org/1whc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whc RCSB], [https://www.ebi.ac.uk/pdbsum/1whc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whc ProSAT], [https://www.topsan.org/Proteins/RSGI/1whc TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/UBXN1_MOUSE UBXN1_MOUSE] Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (By similarity) Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems.<ref>PMID:16709668</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: | [[Category: Doi-Katayama Y]] | ||
[[Category: | [[Category: Hirota H]] | ||
[[Category: | [[Category: Kigawa T]] | ||
[[Category: Koshiba S]] | |||
[[Category: Onuki H]] | |||
[[Category: Tomizawa T]] | |||
[[Category: Yokoyama S]] | |||
Latest revision as of 13:39, 9 May 2024
Solution Structure of RSGI RUH-027, a UBA domain from Mouse cDNA
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