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==Solution structure of the PDZ domain of RGS3==
==Solution structure of the PDZ domain of RGS3==
<StructureSection load='1whd' size='340' side='right'caption='[[1whd]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1whd' size='340' side='right'caption='[[1whd]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1whd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHD FirstGlance]. <br>
<table><tr><td colspan='2'>[[1whd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHD FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA 4930506N09 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whd OCA], [https://pdbe.org/1whd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whd RCSB], [https://www.ebi.ac.uk/pdbsum/1whd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whd ProSAT], [https://www.topsan.org/Proteins/RSGI/1whd TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whd OCA], [https://pdbe.org/1whd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whd RCSB], [https://www.ebi.ac.uk/pdbsum/1whd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whd ProSAT], [https://www.topsan.org/Proteins/RSGI/1whd TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RGS3_MOUSE RGS3_MOUSE]] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.<ref>PMID:11301003</ref> <ref>PMID:12210723</ref>
[https://www.uniprot.org/uniprot/RGS3_MOUSE RGS3_MOUSE] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.<ref>PMID:11301003</ref> <ref>PMID:12210723</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Inoue, M]]
[[Category: Inoue M]]
[[Category: Kigawa, T]]
[[Category: Kigawa T]]
[[Category: Koshiba, S]]
[[Category: Koshiba S]]
[[Category: Nakanishi, T]]
[[Category: Nakanishi T]]
[[Category: Nemoto, N]]
[[Category: Nemoto N]]
[[Category: Structural genomic]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Pdz domain]]
[[Category: Regulator of g-protein signaling]]
[[Category: Rsgi]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/1whd"