1wji: Difference between revisions
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==Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3== | ==Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3== | ||
<StructureSection load='1wji' size='340' side='right'caption='[[1wji | <StructureSection load='1wji' size='340' side='right'caption='[[1wji]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1wji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1wji]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WJI FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wji OCA], [https://pdbe.org/1wji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wji RCSB], [https://www.ebi.ac.uk/pdbsum/1wji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wji ProSAT], [https://www.topsan.org/Proteins/RSGI/1wji TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wji OCA], [https://pdbe.org/1wji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wji RCSB], [https://www.ebi.ac.uk/pdbsum/1wji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wji ProSAT], [https://www.topsan.org/Proteins/RSGI/1wji TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/TDRD3_HUMAN TDRD3_HUMAN] Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.<ref>PMID:18632687</ref> <ref>PMID:15955813</ref> <ref>PMID:21172665</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Inoue | [[Category: Inoue M]] | ||
[[Category: Kamatari | [[Category: Kamatari YO]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Kobayashi | [[Category: Kobayashi N]] | ||
[[Category: Koshiba | [[Category: Koshiba S]] | ||
[[Category: Li | [[Category: Li H]] | ||
[[Category: Miyamoto | [[Category: Miyamoto K]] | ||
[[Category: Nakanishi | [[Category: Nakanishi T]] | ||
[[Category: Tochio N]] | |||
[[Category: Tochio | [[Category: Tomizawa T]] | ||
[[Category: Tomizawa | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
Latest revision as of 13:42, 9 May 2024
Solution Structure of the UBA Domain of Human Tudor Domain Containing Protein 3
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