1wmv: Difference between revisions

Latest revision as of 13:45, 9 May 2024

Solution structure of the second WW domain of WWOX

Structural highlights

1wmv is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

WWOX_HUMAN Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.^[1] ^[2] ^[3] ^[4] ^[5] Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:133239.^[6] ^[7] ^[8] ^[9] ^[10]

Function

WWOX_HUMAN Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.^[11] ^[12] ^[13] ^[14] ^[15] ^[16] ^[17]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Paige AJ, Taylor KJ, Taylor C, Hillier SG, Farrington S, Scott D, Porteous DJ, Smyth JF, Gabra H, Watson JE. WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11417-22. PMID:11572989 doi:10.1073/pnas.191175898
↑ Park SW, Ludes-Meyers J, Zimonjic DB, Durkin ME, Popescu NC, Aldaz CM. Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma. Br J Cancer. 2004 Aug 16;91(4):753-9. PMID:15266310 doi:10.1038/sj.bjc.6602023
↑ Kuroki T, Yendamuri S, Trapasso F, Matsuyama A, Aqeilan RI, Alder H, Rattan S, Cesari R, Nolli ML, Williams NN, Mori M, Kanematsu T, Croce CM. The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis. Clin Cancer Res. 2004 Apr 1;10(7):2459-65. PMID:15073125
↑ Aqeilan RI, Kuroki T, Pekarsky Y, Albagha O, Trapasso F, Baffa R, Huebner K, Edmonds P, Croce CM. Loss of WWOX expression in gastric carcinoma. Clin Cancer Res. 2004 May 1;10(9):3053-8. PMID:15131042
↑ Fabbri M, Iliopoulos D, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, Yendamuri S, Han SY, Amadori D, Huebner K, Croce CM. WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15611-6. Epub 2005 Oct 13. PMID:16223882 doi:0505485102
↑ Paige AJ, Taylor KJ, Taylor C, Hillier SG, Farrington S, Scott D, Porteous DJ, Smyth JF, Gabra H, Watson JE. WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11417-22. PMID:11572989 doi:10.1073/pnas.191175898
↑ Park SW, Ludes-Meyers J, Zimonjic DB, Durkin ME, Popescu NC, Aldaz CM. Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma. Br J Cancer. 2004 Aug 16;91(4):753-9. PMID:15266310 doi:10.1038/sj.bjc.6602023
↑ Kuroki T, Yendamuri S, Trapasso F, Matsuyama A, Aqeilan RI, Alder H, Rattan S, Cesari R, Nolli ML, Williams NN, Mori M, Kanematsu T, Croce CM. The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis. Clin Cancer Res. 2004 Apr 1;10(7):2459-65. PMID:15073125
↑ Aqeilan RI, Kuroki T, Pekarsky Y, Albagha O, Trapasso F, Baffa R, Huebner K, Edmonds P, Croce CM. Loss of WWOX expression in gastric carcinoma. Clin Cancer Res. 2004 May 1;10(9):3053-8. PMID:15131042
↑ Fabbri M, Iliopoulos D, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, Yendamuri S, Han SY, Amadori D, Huebner K, Croce CM. WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15611-6. Epub 2005 Oct 13. PMID:16223882 doi:0505485102
↑ Bednarek AK, Keck-Waggoner CL, Daniel RL, Laflin KJ, Bergsagel PL, Kiguchi K, Brenner AJ, Aldaz CM. WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. Cancer Res. 2001 Nov 15;61(22):8068-73. PMID:11719429
↑ Aqeilan RI, Palamarchuk A, Weigel RJ, Herrero JJ, Pekarsky Y, Croce CM. Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor. Cancer Res. 2004 Nov 15;64(22):8256-61. PMID:15548692 doi:10.1158/0008-5472.CAN-04-2055
↑ Aqeilan RI, Pekarsky Y, Herrero JJ, Palamarchuk A, Letofsky J, Druck T, Trapasso F, Han SY, Melino G, Huebner K, Croce CM. Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4401-6. PMID:15070730 doi:10.1073/pnas.0400805101
↑ Aqeilan RI, Donati V, Palamarchuk A, Trapasso F, Kaou M, Pekarsky Y, Sudol M, Croce CM. WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. Cancer Res. 2005 Aug 1;65(15):6764-72. PMID:16061658 doi:10.1158/0008-5472.CAN-05-1150
↑ Chang NS, Doherty J, Ensign A, Schultz L, Hsu LJ, Hong Q. WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53. J Biol Chem. 2005 Dec 30;280(52):43100-8. Epub 2005 Oct 11. PMID:16219768 doi:M505590200
↑ Hsu LJ, Schultz L, Hong Q, Van Moer K, Heath J, Li MY, Lai FJ, Lin SR, Lee MH, Lo CP, Lin YS, Chen ST, Chang NS. Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1. J Biol Chem. 2009 Jun 5;284(23):16049-59. doi: 10.1074/jbc.M806688200. Epub 2009 , Apr 14. PMID:19366691 doi:10.1074/jbc.M806688200
↑ Bouteille N, Driouch K, Hage PE, Sin S, Formstecher E, Camonis J, Lidereau R, Lallemand F. Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Oncogene. 2009 Jul 16;28(28):2569-80. doi: 10.1038/onc.2009.120. Epub 2009 May, 25. PMID:19465938 doi:10.1038/onc.2009.120

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Paige AJ, Taylor KJ, Taylor C, Hillier SG, Farrington S, Scott D, Porteous DJ, Smyth JF, Gabra H, Watson JE. WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11417-22. PMID:11572989 doi:10.1073/pnas.191175898

[2] Park SW, Ludes-Meyers J, Zimonjic DB, Durkin ME, Popescu NC, Aldaz CM. Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma. Br J Cancer. 2004 Aug 16;91(4):753-9. PMID:15266310 doi:10.1038/sj.bjc.6602023

[3] Kuroki T, Yendamuri S, Trapasso F, Matsuyama A, Aqeilan RI, Alder H, Rattan S, Cesari R, Nolli ML, Williams NN, Mori M, Kanematsu T, Croce CM. The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis. Clin Cancer Res. 2004 Apr 1;10(7):2459-65. PMID:15073125

[4] Aqeilan RI, Kuroki T, Pekarsky Y, Albagha O, Trapasso F, Baffa R, Huebner K, Edmonds P, Croce CM. Loss of WWOX expression in gastric carcinoma. Clin Cancer Res. 2004 May 1;10(9):3053-8. PMID:15131042

[5] Fabbri M, Iliopoulos D, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, Yendamuri S, Han SY, Amadori D, Huebner K, Croce CM. WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15611-6. Epub 2005 Oct 13. PMID:16223882 doi:0505485102

[6] Paige AJ, Taylor KJ, Taylor C, Hillier SG, Farrington S, Scott D, Porteous DJ, Smyth JF, Gabra H, Watson JE. WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11417-22. PMID:11572989 doi:10.1073/pnas.191175898

[7] Park SW, Ludes-Meyers J, Zimonjic DB, Durkin ME, Popescu NC, Aldaz CM. Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma. Br J Cancer. 2004 Aug 16;91(4):753-9. PMID:15266310 doi:10.1038/sj.bjc.6602023

[8] Kuroki T, Yendamuri S, Trapasso F, Matsuyama A, Aqeilan RI, Alder H, Rattan S, Cesari R, Nolli ML, Williams NN, Mori M, Kanematsu T, Croce CM. The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis. Clin Cancer Res. 2004 Apr 1;10(7):2459-65. PMID:15073125

[9] Aqeilan RI, Kuroki T, Pekarsky Y, Albagha O, Trapasso F, Baffa R, Huebner K, Edmonds P, Croce CM. Loss of WWOX expression in gastric carcinoma. Clin Cancer Res. 2004 May 1;10(9):3053-8. PMID:15131042

[10] Fabbri M, Iliopoulos D, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, Yendamuri S, Han SY, Amadori D, Huebner K, Croce CM. WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15611-6. Epub 2005 Oct 13. PMID:16223882 doi:0505485102

[11] Bednarek AK, Keck-Waggoner CL, Daniel RL, Laflin KJ, Bergsagel PL, Kiguchi K, Brenner AJ, Aldaz CM. WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. Cancer Res. 2001 Nov 15;61(22):8068-73. PMID:11719429

[12] Aqeilan RI, Palamarchuk A, Weigel RJ, Herrero JJ, Pekarsky Y, Croce CM. Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor. Cancer Res. 2004 Nov 15;64(22):8256-61. PMID:15548692 doi:10.1158/0008-5472.CAN-04-2055

[13] Aqeilan RI, Pekarsky Y, Herrero JJ, Palamarchuk A, Letofsky J, Druck T, Trapasso F, Han SY, Melino G, Huebner K, Croce CM. Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4401-6. PMID:15070730 doi:10.1073/pnas.0400805101

[14] Aqeilan RI, Donati V, Palamarchuk A, Trapasso F, Kaou M, Pekarsky Y, Sudol M, Croce CM. WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. Cancer Res. 2005 Aug 1;65(15):6764-72. PMID:16061658 doi:10.1158/0008-5472.CAN-05-1150

[15] Chang NS, Doherty J, Ensign A, Schultz L, Hsu LJ, Hong Q. WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53. J Biol Chem. 2005 Dec 30;280(52):43100-8. Epub 2005 Oct 11. PMID:16219768 doi:M505590200

[16] Hsu LJ, Schultz L, Hong Q, Van Moer K, Heath J, Li MY, Lai FJ, Lin SR, Lee MH, Lo CP, Lin YS, Chen ST, Chang NS. Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1. J Biol Chem. 2009 Jun 5;284(23):16049-59. doi: 10.1074/jbc.M806688200. Epub 2009 , Apr 14. PMID:19366691 doi:10.1074/jbc.M806688200

[17] Bouteille N, Driouch K, Hage PE, Sin S, Formstecher E, Camonis J, Lidereau R, Lallemand F. Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Oncogene. 2009 Jul 16;28(28):2569-80. doi: 10.1038/onc.2009.120. Epub 2009 May, 25. PMID:19465938 doi:10.1038/onc.2009.120

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@@ Line 1: / Line 1: @@
 ==Solution structure of the second WW domain of WWOX==
-<StructureSection load='1wmv' size='340' side='right'caption='[[1wmv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='1wmv' size='340' side='right'caption='[[1wmv]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WMV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WMV FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WOX/FOR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [https://pdbe.org/1wmv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [https://www.ebi.ac.uk/pdbsum/1wmv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wmv ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>   Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[https://omim.org/entry/133239 133239]].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>
+[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>   Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[https://omim.org/entry/133239 133239].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>
 == Function ==
-[[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN]] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref> <ref>PMID:15548692</ref> <ref>PMID:15070730</ref> <ref>PMID:16061658</ref> <ref>PMID:16219768</ref> <ref>PMID:19366691</ref> <ref>PMID:19465938</ref>
+[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref> <ref>PMID:15548692</ref> <ref>PMID:15070730</ref> <ref>PMID:16061658</ref> <ref>PMID:16219768</ref> <ref>PMID:19366691</ref> <ref>PMID:19465938</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 25: / Line 25: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Booker, G W]]
+[[Category: Booker GW]]
-[[Category: Colella, A]]
+[[Category: Colella A]]
-[[Category: Kowalski, K]]
+[[Category: Kowalski K]]
-[[Category: Merkel, A L]]
+[[Category: Merkel AL]]
-[[Category: Richards, R I]]
+[[Category: Richards RI]]
-[[Category: All-beta]]
-[[Category: Apoptosis]]
-[[Category: Oxidoreductase]]
-[[Category: Ww domain]]

1wmv: Difference between revisions

Latest revision as of 13:45, 9 May 2024

Solution structure of the second WW domain of WWOX

Structural highlights

Disease

Function

Evolutionary Conservation

References

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