1wug: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
Line 1: Line 1:


==complex structure of PCAF bromodomain with small chemical ligand NP1==
==complex structure of PCAF bromodomain with small chemical ligand NP1==
<StructureSection load='1wug' size='340' side='right'caption='[[1wug]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='1wug' size='340' side='right'caption='[[1wug]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wug]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUG FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wug]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WUG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NP1:N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE'>NP1</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1b91|1b91]], [[1jm4|1jm4]], [[1wum|1wum]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NP1:N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE'>NP1</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PCAF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wug OCA], [https://pdbe.org/1wug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wug RCSB], [https://www.ebi.ac.uk/pdbsum/1wug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wug ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wug OCA], [https://pdbe.org/1wug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wug RCSB], [https://www.ebi.ac.uk/pdbsum/1wug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wug ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/KAT2B_HUMAN KAT2B_HUMAN]] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:8684459</ref> <ref>PMID:9707565</ref> <ref>PMID:10675335</ref> <ref>PMID:23932781</ref>
[https://www.uniprot.org/uniprot/KAT2B_HUMAN KAT2B_HUMAN] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:8684459</ref> <ref>PMID:9707565</ref> <ref>PMID:10675335</ref> <ref>PMID:23932781</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 38: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Histone acetyltransferase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Li, J]]
[[Category: Li J]]
[[Category: Mujtaba, S]]
[[Category: Mujtaba S]]
[[Category: Muller, M]]
[[Category: Muller M]]
[[Category: Pan, C]]
[[Category: Pan C]]
[[Category: Wang, Z]]
[[Category: Wang Z]]
[[Category: Yan, S]]
[[Category: Yan S]]
[[Category: Zeng, L]]
[[Category: Zeng L]]
[[Category: Zhou, M M]]
[[Category: Zhou MM]]
[[Category: Bromodomain]]
[[Category: Chemical ligand]]
[[Category: Histone-acetyltransferase]]
[[Category: Nmr-structure]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/1wug"