1x5s: Difference between revisions
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==Solution structure of RRM domain in A18 hnRNP== | ==Solution structure of RRM domain in A18 hnRNP== | ||
<StructureSection load='1x5s' size='340' side='right'caption='[[1x5s | <StructureSection load='1x5s' size='340' side='right'caption='[[1x5s]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1x5s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1x5s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5S FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5s OCA], [https://pdbe.org/1x5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5s RCSB], [https://www.ebi.ac.uk/pdbsum/1x5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5s ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5s TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5s OCA], [https://pdbe.org/1x5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5s RCSB], [https://www.ebi.ac.uk/pdbsum/1x5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5s ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5s TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CIRBP_HUMAN CIRBP_HUMAN] Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.<ref>PMID:11574538</ref> <ref>PMID:16513844</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Inoue | [[Category: Inoue M]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Muto | [[Category: Muto Y]] | ||
[[Category: Sato A]] | |||
[[Category: Sato | [[Category: Shirouzu M]] | ||
[[Category: Shirouzu | [[Category: Terada T]] | ||
[[Category: Terada | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
