8oxr: Difference between revisions

Latest revision as of 05:20, 15 May 2024

Structure of the N-terminal didomain d1_d2 of the Thrombospondin type-1 domain-containing 7A

Structural highlights

8oxr is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.3Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

THS7A_HUMAN Autoantibodies against THSD7A have been detected in serum and glomeruli from patients with idiopathic membranous nephropathy (PubMed:25394321). The majority of the autoantibodies react with the two most N-terminal TSP type-1 domains (PubMed:29555830).^[1] ^[2]

Function

THS7A_HUMAN Plays a role in actin cytoskeleton rearrangement.^[3] The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.^[4]

References

↑ Tomas NM, Beck LH Jr, Meyer-Schwesinger C, Seitz-Polski B, Ma H, Zahner G, Dolla G, Hoxha E, Helmchen U, Dabert-Gay AS, Debayle D, Merchant M, Klein J, Salant DJ, Stahl RAK, Lambeau G. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N Engl J Med. 2014 Dec 11;371(24):2277-2287. PMID:25394321 doi:10.1056/NEJMoa1409354
↑ Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NM. The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy. J Am Soc Nephrol. 2018 May;29(5):1536-1548. PMID:29555830 doi:10.1681/ASN.2017070805
↑ Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA. Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. J Clin Invest. 2016 Jul 1;126(7):2519-32. PMID:27214550 doi:10.1172/JCI85265
↑ Kuo MW, Wang CH, Wu HC, Chang SJ, Chuang YJ. Soluble THSD7A is an N-glycoprotein that promotes endothelial cell migration and tube formation in angiogenesis. PLoS One. 2011;6(12):e29000. PMID:22194972 doi:10.1371/journal.pone.0029000

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OCA

[1] Tomas NM, Beck LH Jr, Meyer-Schwesinger C, Seitz-Polski B, Ma H, Zahner G, Dolla G, Hoxha E, Helmchen U, Dabert-Gay AS, Debayle D, Merchant M, Klein J, Salant DJ, Stahl RAK, Lambeau G. Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N Engl J Med. 2014 Dec 11;371(24):2277-2287. PMID:25394321 doi:10.1056/NEJMoa1409354

[2] Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NM. The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy. J Am Soc Nephrol. 2018 May;29(5):1536-1548. PMID:29555830 doi:10.1681/ASN.2017070805

[3] Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA. Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. J Clin Invest. 2016 Jul 1;126(7):2519-32. PMID:27214550 doi:10.1172/JCI85265

[4] Kuo MW, Wang CH, Wu HC, Chang SJ, Chuang YJ. Soluble THSD7A is an N-glycoprotein that promotes endothelial cell migration and tube formation in angiogenesis. PLoS One. 2011;6(12):e29000. PMID:22194972 doi:10.1371/journal.pone.0029000

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8oxr is ON HOLD  until Paper Publication
+==Structure of the N-terminal didomain d1_d2 of the Thrombospondin type-1 domain-containing 7A==
+<StructureSection load='8oxr' size='340' side='right'caption='[[8oxr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-Authors: Bochel, A., Mortensen, S.A., Chojnowski, G., Wilmanns, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8oxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OXR FirstGlance]. <br>
-Description: Structure of the N-terminal didomain d1_d2 of the Thrombospondin type-1 domain-containing 7A
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oxr OCA], [https://pdbe.org/8oxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oxr RCSB], [https://www.ebi.ac.uk/pdbsum/8oxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oxr ProSAT]</span></td></tr>
-[[Category: Wilmanns, M]]
+</table>
-[[Category: Mortensen, S.A]]
+== Disease ==
-[[Category: Chojnowski, G]]
+[https://www.uniprot.org/uniprot/THS7A_HUMAN THS7A_HUMAN] Autoantibodies against THSD7A have been detected in serum and glomeruli from patients with idiopathic membranous nephropathy (PubMed:25394321). The majority of the autoantibodies react with the two most N-terminal TSP type-1 domains (PubMed:29555830).<ref>PMID:25394321</ref> <ref>PMID:29555830</ref>
-[[Category: Bochel, A]]
+== Function ==
+[https://www.uniprot.org/uniprot/THS7A_HUMAN THS7A_HUMAN] Plays a role in actin cytoskeleton rearrangement.<ref>PMID:27214550</ref>   The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.<ref>PMID:22194972</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Bochel A]]
+[[Category: Chojnowski G]]
+[[Category: Mortensen SA]]
+[[Category: Wilmanns M]]

8oxr: Difference between revisions

Latest revision as of 05:20, 15 May 2024

Structure of the N-terminal didomain d1_d2 of the Thrombospondin type-1 domain-containing 7A

Structural highlights

Disease

Function

References

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