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==Solution structure and RNA interactions of the RNA recognition motif from eukaryotic translation initiation factor 4B==
==Solution structure and RNA interactions of the RNA recognition motif from eukaryotic translation initiation factor 4B==
<StructureSection load='2j76' size='340' side='right'caption='[[2j76]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2j76' size='340' side='right'caption='[[2j76]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2j76]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J76 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2J76 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2j76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J76 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wi8|1wi8]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2j76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j76 OCA], [http://pdbe.org/2j76 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j76 RCSB], [http://www.ebi.ac.uk/pdbsum/2j76 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j76 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j76 OCA], [https://pdbe.org/2j76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j76 RCSB], [https://www.ebi.ac.uk/pdbsum/2j76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j76 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IF4B_HUMAN IF4B_HUMAN]] Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.  
[https://www.uniprot.org/uniprot/IF4B_HUMAN IF4B_HUMAN] Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Curry, S]]
[[Category: Curry S]]
[[Category: Fleming, K]]
[[Category: Fleming K]]
[[Category: Ghuman, J]]
[[Category: Ghuman J]]
[[Category: Matthews, S]]
[[Category: Matthews S]]
[[Category: Simpson, P]]
[[Category: Simpson P]]
[[Category: Szendroi, A]]
[[Category: Szendroi A]]
[[Category: Yuan, X M]]
[[Category: Yuan XM]]
[[Category: Initiation factor]]
[[Category: Phosphorylation]]
[[Category: Protein biosynthesis]]
[[Category: Rbd]]
[[Category: Rna binding domain]]
[[Category: Rna recognition motif]]
[[Category: Rna-binding]]
[[Category: Rnp]]
[[Category: Rrm]]
[[Category: Translation]]
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