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==Solution structure of the Carbon Storage Regulator protein CsrA==
==Solution structure of the Carbon Storage Regulator protein CsrA==
<StructureSection load='1y00' size='340' side='right'caption='[[1y00]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1y00' size='340' side='right'caption='[[1y00]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1y00]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y00 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">csrA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [https://pdbe.org/1y00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [https://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y00 ProSAT], [https://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y00 OCA], [https://pdbe.org/1y00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y00 RCSB], [https://www.ebi.ac.uk/pdbsum/1y00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y00 ProSAT], [https://www.topsan.org/Proteins/BSGI/1y00 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CSRA_ECOLI CSRA_ECOLI]] Binds to mRNA to regulate post-transcriptional activity. Affects glycogen biosynthesis, gluconeogenesis, cell size and surface properties. Regulates glycogen synthesis under both aerobic and anaerobic conditions. Seems to accelerate the degradation of glg gene transcripts, potentially through selective RNA binding. Acts to inhibit interaction between the LetD protein and the A subunit of DNA gyrase. Also required for motility and flagellum biosynthesis through the post-transcriptional activation of flhDC expression. This involves binding to and stabilization of the flhDC message by CsrA. Binds to and reduces levels of probable diguanylate cyclases ycdT and ydeH.<ref>PMID:11298291</ref> <ref>PMID:18713317</ref> <ref>PMID:19460094</ref>
[https://www.uniprot.org/uniprot/CSRA_ECOLI CSRA_ECOLI] Binds to mRNA to regulate post-transcriptional activity. Affects glycogen biosynthesis, gluconeogenesis, cell size and surface properties. Regulates glycogen synthesis under both aerobic and anaerobic conditions. Seems to accelerate the degradation of glg gene transcripts, potentially through selective RNA binding. Acts to inhibit interaction between the LetD protein and the A subunit of DNA gyrase. Also required for motility and flagellum biosynthesis through the post-transcriptional activation of flhDC expression. This involves binding to and stabilization of the flhDC message by CsrA. Binds to and reduces levels of probable diguanylate cyclases ycdT and ydeH.<ref>PMID:11298291</ref> <ref>PMID:18713317</ref> <ref>PMID:19460094</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Gehring K]]
[[Category: Gehring, K]]
[[Category: Gutierrez P]]
[[Category: Gutierrez, P]]
[[Category: Li Y]]
[[Category: Li, Y]]
[[Category: Liu Q]]
[[Category: Liu, Q]]
[[Category: Osborne MJ]]
[[Category: Osborne, M J]]
[[Category: Bsgi]]
[[Category: Carbon storage regulation]]
[[Category: Rna binding protein]]
Retrieved from "https://proteopedia.org/1y00"