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==Solution structure of the N-terminal SH3 domain of DRK==
==Solution structure of the N-terminal SH3 domain of DRK==
<StructureSection load='2a36' size='340' side='right'caption='[[2a36]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2a36' size='340' side='right'caption='[[2a36]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2a36]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A36 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2a36]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A36 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2a37|2a37]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">drk, E(sev)2B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a36 OCA], [https://pdbe.org/2a36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a36 RCSB], [https://www.ebi.ac.uk/pdbsum/2a36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a36 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a36 OCA], [https://pdbe.org/2a36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a36 RCSB], [https://www.ebi.ac.uk/pdbsum/2a36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a36 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DRK_DROME DRK_DROME]] Required for proper signaling by sevenless. May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex.<ref>PMID:8462097</ref> <ref>PMID:8462098</ref>
[https://www.uniprot.org/uniprot/GRAP_DROME GRAP_DROME] Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as sev and Ack (PubMed:8462097, PubMed:22615583, PubMed:8462098). Required for proper signaling by sevenless (PubMed:8462097, PubMed:8462098). May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex (PubMed:8462097, PubMed:8462098). Required for functional and morphological integrities of the scolopidia, sensory neurons and the antennal mechanosensory and motor center (AMMC) brain neuropil (PubMed:30610177). Required for Ack-dependent suppression of apoptosis in the eye (PubMed:22615583).<ref>PMID:22615583</ref> <ref>PMID:30610177</ref> <ref>PMID:8462097</ref> <ref>PMID:8462098</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bezsonova, I]]
[[Category: Bezsonova I]]
[[Category: Choy, W Y]]
[[Category: Choy W-Y]]
[[Category: Forman-Kay, J D]]
[[Category: Forman-Kay JD]]
[[Category: Singer, A]]
[[Category: Singer A]]
[[Category: Tollinger, M]]
[[Category: Tollinger M]]
[[Category: Drk]]
[[Category: Drosophila melanogaster]]
[[Category: Sh3 fragment]]
[[Category: Signaling protein]]
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