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==Structural and functional analysis of ADA2 alpha swirm domain==
==Structural and functional analysis of ADA2 alpha swirm domain==
<StructureSection load='2aqf' size='340' side='right'caption='[[2aqf]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2aqf' size='340' side='right'caption='[[2aqf]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2aqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AQF FirstGlance]. <br>
<table><tr><td colspan='2'>[[2aqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AQF FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2aqe|2aqe]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tada21 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aqf OCA], [https://pdbe.org/2aqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aqf RCSB], [https://www.ebi.ac.uk/pdbsum/2aqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aqf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aqf OCA], [https://pdbe.org/2aqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aqf RCSB], [https://www.ebi.ac.uk/pdbsum/2aqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aqf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TAD2A_MOUSE TAD2A_MOUSE] Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Qian, C]]
[[Category: Qian C]]
[[Category: Zeng, L]]
[[Category: Zeng L]]
[[Category: Zhang, Q]]
[[Category: Zhang Q]]
[[Category: Zhou, M M]]
[[Category: Zhou M-M]]
[[Category: Helix-turn-helix]]
[[Category: Transcription]]
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