2myo: Difference between revisions
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==SOLUTION STRUCTURE OF MYOTROPHIN, NMR, MINIMIZED AVERAGE STRUCTURE== | ==SOLUTION STRUCTURE OF MYOTROPHIN, NMR, MINIMIZED AVERAGE STRUCTURE== | ||
<StructureSection load='2myo' size='340' side='right'caption='[[2myo | <StructureSection load='2myo' size='340' side='right'caption='[[2myo]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2myo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MYO FirstGlance]. <br> | <table><tr><td colspan='2'>[[2myo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MYO FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2myo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2myo OCA], [https://pdbe.org/2myo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2myo RCSB], [https://www.ebi.ac.uk/pdbsum/2myo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2myo ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2myo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2myo OCA], [https://pdbe.org/2myo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2myo RCSB], [https://www.ebi.ac.uk/pdbsum/2myo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2myo ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/MTPN_RAT MTPN_RAT] Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.<ref>PMID:17041682</ref> <ref>PMID:18693253</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Nanduri | [[Category: Nanduri S]] | ||
[[Category: Qin | [[Category: Qin J]] | ||
[[Category: Sen | [[Category: Sen S]] | ||
[[Category: Yang | [[Category: Yang Y]] | ||
