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==Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of an the inhibitor BIIB021==
==Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of an the inhibitor BIIB021==
<StructureSection load='3o6o' size='340' side='right' caption='[[3o6o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3o6o' size='340' side='right'caption='[[3o6o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3o6o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O6O FirstGlance]. <br>
<table><tr><td colspan='2'>[[3o6o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O6O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=94M:6-CHLORO-9-[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]-9H-PURIN-2-AMINE'>94M</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tb10.26.1080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=94M:6-CHLORO-9-[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]-9H-PURIN-2-AMINE'>94M</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o6o OCA], [http://pdbe.org/3o6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o6o RCSB], [http://www.ebi.ac.uk/pdbsum/3o6o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o6o ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o6o OCA], [https://pdbe.org/3o6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o6o RCSB], [https://www.ebi.ac.uk/pdbsum/3o6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o6o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q389P1_TRYB2 Q389P1_TRYB2]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o6/3o6o_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o6/3o6o_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3o6o" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3o6o" style="background-color:#fffaf0;"></div>
==See Also==
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Bochkarev, A]]
[[Category: Trypanosoma brucei]]
[[Category: Bountra, C]]
[[Category: Arrowsmith CH]]
[[Category: Cossar, D]]
[[Category: Bochkarev A]]
[[Category: Edwards, A M]]
[[Category: Bountra C]]
[[Category: Fairlamb, A H]]
[[Category: Cossar D]]
[[Category: Ferguson, M A.J]]
[[Category: Edwards AM]]
[[Category: Hills, T]]
[[Category: Fairlamb AH]]
[[Category: Hui, R]]
[[Category: Ferguson MAJ]]
[[Category: Hutchinson, A]]
[[Category: Hills T]]
[[Category: Kozieradzki, I]]
[[Category: Hui R]]
[[Category: Li, Y]]
[[Category: Hutchinson A]]
[[Category: MacKenzie, C]]
[[Category: Kozieradzki I]]
[[Category: Pizarro, J C]]
[[Category: Li Y]]
[[Category: Structural genomic]]
[[Category: MacKenzie C]]
[[Category: Sullivan, H]]
[[Category: Pizarro JC]]
[[Category: Thompson, S]]
[[Category: Sullivan H]]
[[Category: Weadge, J]]
[[Category: Thompson S]]
[[Category: Weigelt, J]]
[[Category: Weadge J]]
[[Category: Wernimont, A K]]
[[Category: Weigelt J]]
[[Category: Wyatt, P]]
[[Category: Wernimont AK]]
[[Category: African sleeping sickness]]
[[Category: Wyatt P]]
[[Category: Chaperone]]
[[Category: Heat shock protein]]
[[Category: Sgc]]
[[Category: Trypanosoma]]
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