5uwx: Difference between revisions
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<StructureSection load='5uwx' size='340' side='right'caption='[[5uwx]], [[Resolution|resolution]] 1.85Å' scene=''> | <StructureSection load='5uwx' size='340' side='right'caption='[[5uwx]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5uwx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[5uwx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UWX FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8L7:N-{2-CHLORO-5-[({2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}CARBAMOYL)AMINO]PHENYL}-ALPHA-D-RIBOFURANOSYLAMINE'>8L7</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8L7:N-{2-CHLORO-5-[({2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}CARBAMOYL)AMINO]PHENYL}-ALPHA-D-RIBOFURANOSYLAMINE'>8L7</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uwx OCA], [https://pdbe.org/5uwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uwx RCSB], [https://www.ebi.ac.uk/pdbsum/5uwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uwx ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uwx OCA], [https://pdbe.org/5uwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uwx RCSB], [https://www.ebi.ac.uk/pdbsum/5uwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uwx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/A0A127ELD1_CLOPF A0A127ELD1_CLOPF] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Clostridium perfringens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Anderson | [[Category: Anderson WF]] | ||
[[Category: Gollapalli DR]] | |||
[[Category: Gollapalli | [[Category: Gu M]] | ||
[[Category: Gu | [[Category: Hedstrom L]] | ||
[[Category: Hedstrom | [[Category: Joachimiak A]] | ||
[[Category: Joachimiak | [[Category: Kim Y]] | ||
[[Category: Kim | [[Category: Makowska-Grzyska M]] | ||
[[Category: Makowska-Grzyska | [[Category: Maltseva N]] | ||
[[Category: Maltseva | [[Category: Mulligan R]] | ||
[[Category: Mulligan | |||
Latest revision as of 10:05, 22 May 2024
Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P176
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