6s2c: Difference between revisions

Latest revision as of 10:13, 22 May 2024

Acquired functional capsid structures in metazoan totivirus-like dsRNA virus.

Structural highlights

6s2c is a 2 chain structure with sequence from Omono River virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.2Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

E1CI69_9VIRU

Publication Abstract from PubMed

Non-enveloped icosahedral double-stranded RNA (dsRNA) viruses possess multifunctional capsids required for their proliferation. Whereas protozoan/fungal dsRNA viruses have a relatively simple capsid structure, which suffices for the intracellular phase in their life cycle, metazoan dsRNA viruses have acquired additional structural features as an adaptation for extracellular cell-to-cell transmission in multicellular hosts. Here, we present the first atomic model of a metazoan dsRNA totivirus-like virus and the structure reveals three unique structural traits: a C-terminal interlocking arm, surface projecting loops, and an obstruction at the pore on the 5-fold symmetry axis. These traits are keys to understanding the capsid functions of metazoan dsRNA viruses, such as particle stability and formation, cell entry, and endogenous intraparticle transcription of mRNA. On the basis of molecular dynamics simulations of the obstructed pore, we propose a possible mechanism of intraparticle transcription in totivirus-like viruses, which dynamically switches between open and closed states of the pore(s).

Acquired Functional Capsid Structures in Metazoan Totivirus-like dsRNA Virus.,Okamoto K, Ferreira RJ, Larsson DSD, Maia FRNC, Isawa H, Sawabe K, Murata K, Hajdu J, Iwasaki K, Kasson PM, Miyazaki N Structure. 2020 May 10. pii: S0969-2126(20)30137-4. doi:, 10.1016/j.str.2020.04.016. PMID:32413288^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Okamoto K, Ferreira RJ, Larsson DSD, Maia FRNC, Isawa H, Sawabe K, Murata K, Hajdu J, Iwasaki K, Kasson PM, Miyazaki N. Acquired Functional Capsid Structures in Metazoan Totivirus-like dsRNA Virus. Structure. 2020 May 10. pii: S0969-2126(20)30137-4. doi:, 10.1016/j.str.2020.04.016. PMID:32413288 doi:https://dx.doi.org/10.1016/j.str.2020.04.016

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OCA

[1] Okamoto K, Ferreira RJ, Larsson DSD, Maia FRNC, Isawa H, Sawabe K, Murata K, Hajdu J, Iwasaki K, Kasson PM, Miyazaki N. Acquired Functional Capsid Structures in Metazoan Totivirus-like dsRNA Virus. Structure. 2020 May 10. pii: S0969-2126(20)30137-4. doi:, 10.1016/j.str.2020.04.016. PMID:32413288 doi:https://dx.doi.org/10.1016/j.str.2020.04.016

[1]

@@ Line 3: / Line 3: @@
 <StructureSection load='6s2c' size='340' side='right'caption='[[6s2c]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6s2c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Omono_river_virus Omono river virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S2C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S2C FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6s2c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Omono_River_virus Omono River virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S2C FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s2c OCA], [http://pdbe.org/6s2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s2c RCSB], [http://www.ebi.ac.uk/pdbsum/6s2c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s2c ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s2c OCA], [https://pdbe.org/6s2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s2c RCSB], [https://www.ebi.ac.uk/pdbsum/6s2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s2c ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/E1CI69_9VIRU E1CI69_9VIRU]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Omono river virus]]
+[[Category: Omono River virus]]
-[[Category: Hajdu, J]]
+[[Category: Hajdu J]]
-[[Category: Iwasaki, K]]
+[[Category: Iwasaki K]]
-[[Category: Larsson, S D.D]]
+[[Category: Larsson SDD]]
-[[Category: Maia, R N.C F]]
+[[Category: Maia RNCF]]
-[[Category: Miyazaki, N]]
+[[Category: Miyazaki N]]
-[[Category: Murata, K]]
+[[Category: Murata K]]
-[[Category: Okamoto, K]]
+[[Category: Okamoto K]]
-[[Category: Capsid]]
-[[Category: Dsrna]]
-[[Category: Mosquito]]
-[[Category: Totiviridae]]
-[[Category: Totivirus]]
-[[Category: Totivirus-like virus]]
-[[Category: Virus]]

6s2c: Difference between revisions

Latest revision as of 10:13, 22 May 2024

Acquired functional capsid structures in metazoan totivirus-like dsRNA virus.

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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