2awt: Difference between revisions
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==Solution Structure of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2)== | ==Solution Structure of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2)== | ||
<StructureSection load='2awt' size='340' side='right'caption='[[2awt | <StructureSection load='2awt' size='340' side='right'caption='[[2awt]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2awt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2awt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AWT FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2awt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awt OCA], [https://pdbe.org/2awt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2awt RCSB], [https://www.ebi.ac.uk/pdbsum/2awt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2awt ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2awt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awt OCA], [https://pdbe.org/2awt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2awt RCSB], [https://www.ebi.ac.uk/pdbsum/2awt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2awt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chang | [[Category: Chang CF]] | ||
[[Category: Chang | [[Category: Chang CK]] | ||
[[Category: Chung | [[Category: Chung TL]] | ||
[[Category: Huang | [[Category: Huang TH]] | ||
[[Category: Li | [[Category: Li SSL]] | ||
[[Category: Wang | [[Category: Wang YH]] | ||
Latest revision as of 11:18, 22 May 2024
Solution Structure of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2)
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