2bmx: Difference between revisions
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<StructureSection load='2bmx' size='340' side='right'caption='[[2bmx]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='2bmx' size='340' side='right'caption='[[2bmx]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2bmx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2bmx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BMX FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bmx OCA], [https://pdbe.org/2bmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bmx RCSB], [https://www.ebi.ac.uk/pdbsum/2bmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bmx ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bmx OCA], [https://pdbe.org/2bmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bmx RCSB], [https://www.ebi.ac.uk/pdbsum/2bmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bmx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/AHPC_MYCTU AHPC_MYCTU] Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Together with AhpD, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in detoxification of isoniazid.<ref>PMID:10766746</ref> <ref>PMID:11799204</ref> <ref>PMID:12084012</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: Alzari PM]] | |||
[[Category: Alzari | [[Category: Guimaraes BG]] | ||
[[Category: Guimaraes | |||
