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==Solution structure of the TPR domain from Protein phosphatase 5 in complex with Hsp90 derived peptide==
==Solution structure of the TPR domain from Protein phosphatase 5 in complex with Hsp90 derived peptide==
<StructureSection load='2bug' size='340' side='right'caption='[[2bug]], [[NMR_Ensembles_of_Models | 19 NMR models]]' scene=''>
<StructureSection load='2bug' size='340' side='right'caption='[[2bug]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2bug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BUG FirstGlance]. <br>
<table><tr><td colspan='2'>[[2bug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BUG FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a17|1a17]], [[1s95|1s95]], [[1wao|1wao]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bug OCA], [https://pdbe.org/2bug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bug RCSB], [https://www.ebi.ac.uk/pdbsum/2bug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bug ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bug OCA], [https://pdbe.org/2bug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bug RCSB], [https://www.ebi.ac.uk/pdbsum/2bug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bug ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PPP5_HUMAN PPP5_HUMAN] May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Barford D]]
[[Category: Barford, D]]
[[Category: Cliff MJ]]
[[Category: Cliff, M J]]
[[Category: Harris R]]
[[Category: Harris, R]]
[[Category: Ladbury JE]]
[[Category: Ladbury, J E]]
[[Category: Williams MA]]
[[Category: Williams, M A]]
[[Category: Hsp90 binding]]
[[Category: Hydrolase]]
[[Category: Iron]]
[[Category: Manganese]]
[[Category: Metal-binding]]
[[Category: Protein phosphatase]]
[[Category: Tetratricopeptide domain]]
Retrieved from "https://proteopedia.org/2bug"