2dce: Difference between revisions
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==Solution structure of the SWIRM domain of human KIAA1915 protein== | ==Solution structure of the SWIRM domain of human KIAA1915 protein== | ||
<StructureSection load='2dce' size='340' side='right'caption='[[2dce | <StructureSection load='2dce' size='340' side='right'caption='[[2dce]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dce]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2dce]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DCE FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dce OCA], [https://pdbe.org/2dce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dce RCSB], [https://www.ebi.ac.uk/pdbsum/2dce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dce ProSAT], [https://www.topsan.org/Proteins/RSGI/2dce TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dce OCA], [https://pdbe.org/2dce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dce RCSB], [https://www.ebi.ac.uk/pdbsum/2dce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dce ProSAT], [https://www.topsan.org/Proteins/RSGI/2dce TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/MYSM1_HUMAN MYSM1_HUMAN] Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.<ref>PMID:17707232</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Inoue | [[Category: Inoue M]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Koshiba | [[Category: Koshiba S]] | ||
[[Category: Tanaka A]] | |||
[[Category: Tanaka | [[Category: Tochio N]] | ||
[[Category: Tochio | [[Category: Umehara T]] | ||
[[Category: Umehara | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | [[Category: Yoneyama M]] | ||
[[Category: Yoneyama | |||
