2de4: Difference between revisions

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<StructureSection load='2de4' size='340' side='right'caption='[[2de4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2de4' size='340' side='right'caption='[[2de4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2de4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhosg Rhosg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DE4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2de4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._IGTS8 Rhodococcus sp. IGTS8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DE4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BPS:1,1-BIPHENYL-2-SULFINIC+ACID'>BPS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2de2|2de2]], [[2de3|2de3]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BPS:1,1-BIPHENYL-2-SULFINIC+ACID'>BPS</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DSZB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=54064 RHOSG])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/2'-hydroxybiphenyl-2-sulfinate_desulfinase 2'-hydroxybiphenyl-2-sulfinate desulfinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.13.1.3 3.13.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2de4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2de4 OCA], [https://pdbe.org/2de4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2de4 RCSB], [https://www.ebi.ac.uk/pdbsum/2de4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2de4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2de4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2de4 OCA], [https://pdbe.org/2de4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2de4 RCSB], [https://www.ebi.ac.uk/pdbsum/2de4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2de4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SOXB_RHOSG SOXB_RHOSG]] Part of a pathway to remove covalently bound sulfur from dibenzothiophene (DBT) without breaking carbon-carbon bonds. This enzyme metabolizes DBT-sulfone (DBTO2 or DBT 5,5-dioxide) to 2-hydroxybiphenyl (2-HBP).  
[https://www.uniprot.org/uniprot/DSZB_RHOSG DSZB_RHOSG] Catalyzes the third and final step of the '4S' desulfurization pathway that removes covalently bound sulfur from dibenzothiophene (DBT) without breaking carbon-carbon bonds. Oxidizes 2-(2'-hydroxyphenyl)benzene sulphinate (HBPS) to 2-hydroxybiphenyl (HBP) plus sulfite (PubMed:7961424, PubMed:7574582, PubMed:9634856, PubMed:9308179, PubMed:31545606). The rate-limiting step of the '4S' desulfurization pathway (PubMed:9308179, PubMed:31545606). The pathway substrate specificity has been augmented using mutagenesis, however no mutations allowed use of alkylated thiophenes (PubMed:11823208).<ref>PMID:11823208</ref> <ref>PMID:31545606</ref> <ref>PMID:7574582</ref> <ref>PMID:7961424</ref> <ref>PMID:9308179</ref> <ref>PMID:9634856</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 2'-hydroxybiphenyl-2-sulfinate desulfinase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Rhosg]]
[[Category: Rhodococcus sp. IGTS8]]
[[Category: Izumi, Y]]
[[Category: Izumi Y]]
[[Category: Lee, W C]]
[[Category: Lee WC]]
[[Category: Matsubara, T]]
[[Category: Matsubara T]]
[[Category: Ohshiro, T]]
[[Category: Ohshiro T]]
[[Category: Tanokura, M]]
[[Category: Tanokura M]]
[[Category: Alpha-beta]]
[[Category: Hydrolase]]
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