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==Solution structure of the CHY zinc finger domain of the RING finger and CHY zinc finger domain-containing protein 1 from Mus musculus==
==Solution structure of the CHY zinc finger domain of the RING finger and CHY zinc finger domain-containing protein 1 from Mus musculus==
<StructureSection load='2dkt' size='340' side='right'caption='[[2dkt]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2dkt' size='340' side='right'caption='[[2dkt]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2dkt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DKT FirstGlance]. <br>
<table><tr><td colspan='2'>[[2dkt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DKT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rchy1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dkt OCA], [https://pdbe.org/2dkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dkt RCSB], [https://www.ebi.ac.uk/pdbsum/2dkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dkt ProSAT], [https://www.topsan.org/Proteins/RSGI/2dkt TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dkt OCA], [https://pdbe.org/2dkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dkt RCSB], [https://www.ebi.ac.uk/pdbsum/2dkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dkt ProSAT], [https://www.topsan.org/Proteins/RSGI/2dkt TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ZN363_MOUSE ZN363_MOUSE]] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Increases AR transcription factor activity. Monoubiquitinates the translesion DNA polymerase POLH (By similarity). Contributes to the regulation of the cell cycle progression.  
[https://www.uniprot.org/uniprot/ZN363_MOUSE ZN363_MOUSE] Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Increases AR transcription factor activity. Monoubiquitinates the translesion DNA polymerase POLH (By similarity). Contributes to the regulation of the cell cycle progression.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Inoue, M]]
[[Category: Inoue M]]
[[Category: Kigawa, T]]
[[Category: Kigawa T]]
[[Category: Koshiba, S]]
[[Category: Koshiba S]]
[[Category: Miyamoto, K]]
[[Category: Miyamoto K]]
[[Category: Structural genomic]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Chy zinc finger domain]]
[[Category: Metal binding protein]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rchy1]]
[[Category: Ring finger and chy zinc finger domain-containing protein 1]]
[[Category: Rsgi]]
Retrieved from "https://proteopedia.org/2dkt"