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==Solution structure of the RGS domain of human Regulator of G-protein signaling 10==
==Solution structure of the RGS domain of human Regulator of G-protein signaling 10==
<StructureSection load='2dlr' size='340' side='right'caption='[[2dlr]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2dlr' size='340' side='right'caption='[[2dlr]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2dlr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DLR FirstGlance]. <br>
<table><tr><td colspan='2'>[[2dlr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DLR FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RGS10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dlr OCA], [https://pdbe.org/2dlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dlr RCSB], [https://www.ebi.ac.uk/pdbsum/2dlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dlr ProSAT], [https://www.topsan.org/Proteins/RSGI/2dlr TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dlr OCA], [https://pdbe.org/2dlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dlr RCSB], [https://www.ebi.ac.uk/pdbsum/2dlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dlr ProSAT], [https://www.topsan.org/Proteins/RSGI/2dlr TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RGS10_HUMAN RGS10_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.  
[https://www.uniprot.org/uniprot/RGS10_HUMAN RGS10_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hayashi, F]]
[[Category: Hayashi F]]
[[Category: Nagashima, T]]
[[Category: Nagashima T]]
[[Category: Structural genomic]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Zhang HP]]
[[Category: Zhang, H P]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Regulator of g-protein signaling 10]]
[[Category: Rgs domain]]
[[Category: Rgs10]]
[[Category: Rsgi]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/2dlr"