2e2z: Difference between revisions
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==Solution NMR structure of yeast Tim15, co-chaperone of mitochondrial Hsp70== | ==Solution NMR structure of yeast Tim15, co-chaperone of mitochondrial Hsp70== | ||
<StructureSection load='2e2z' size='340' side='right'caption='[[2e2z | <StructureSection load='2e2z' size='340' side='right'caption='[[2e2z]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2e2z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2e2z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E2Z FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2z OCA], [https://pdbe.org/2e2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e2z RCSB], [https://www.ebi.ac.uk/pdbsum/2e2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2z ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e2z OCA], [https://pdbe.org/2e2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e2z RCSB], [https://www.ebi.ac.uk/pdbsum/2e2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e2z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ZIM17_YEAST ZIM17_YEAST] Involved in protein import into mitochondria. Acts as a Hsp70-specific chaperone that prevents self-aggregation of the matrix Hsp70 chaperones SSC1 (mtHSP70) and SSQ1, thereby maintaining their function in mitochondrial protein import and Fe/S protein biosynthesis. May act together with PAM18 as co-chaperone to facilitate recognition and folding of imported proteins by SSC1 in the mitochondrial matrix.<ref>PMID:15383543</ref> <ref>PMID:15642367</ref> <ref>PMID:15719019</ref> <ref>PMID:15992824</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Endo | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Maeda | [[Category: Endo T]] | ||
[[Category: Momose | [[Category: Maeda M]] | ||
[[Category: Ohshima | [[Category: Momose T]] | ||
[[Category: Ohshima C]] | |||
