2ed0: Difference between revisions
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==Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)== | ==Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)== | ||
<StructureSection load='2ed0' size='340' side='right'caption='[[2ed0 | <StructureSection load='2ed0' size='340' side='right'caption='[[2ed0]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ed0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ed0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ED0 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ed0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ed0 OCA], [https://pdbe.org/2ed0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ed0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ed0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ed0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ed0 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ed0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ed0 OCA], [https://pdbe.org/2ed0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ed0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ed0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ed0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ed0 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ABI2_HUMAN ABI2_HUMAN] May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.<ref>PMID:7590236</ref> <ref>PMID:8649853</ref> <ref>PMID:10498863</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Abe | [[Category: Abe H]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Miyamoto | [[Category: Miyamoto K]] | ||
[[Category: Saito K]] | |||
[[Category: Saito | [[Category: Tochio N]] | ||
[[Category: Tochio | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
Latest revision as of 18:49, 29 May 2024
Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)
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